What is granulocytopenia?
The term granulocytopenia concerns a reduced number of granulocytes or on white blood cells that appear when viewed under a microscope covered with granules. Basophils, eosinophils and neutrophils that make up this cell group are responsible for different body immune functions. These specific developmental or existing white blood cells can affect the varieties of circumstances. Autoimmune disorders or certain health conditions, infections and medical treatment can all contribute to granulocytopenia. Suffering may be a inherited condition, and some populations seem to be affected than others, including blacks and Yemeni Jews.
Basophils will start inflammatory reactions. This response involves the release of histamine that causes blood vessel dilation, increases overall circulation and allows immune defense to arrive rapidly. Eosinophils primarily increase during the allergic reactions, but also regulate the function of immune cells, repair the tissue repair and participate in the destruction of tumor cells. Neutrophils include most of the granulesThe white cells and cause the consumption of foreign cells perceived as a threat to the body.
Autoimmune disorders and infections affect the number of granulocytes when cells leave circulating blood and migrate into tissues infected with disruption or microbes. Granulocytopenia often occurs in people with Crohn's disease, lupus or rheumatoid arthritis. Because blood cells have a specific lifetime, a disease that causes bone marrow failure disrupts the production of new cells that replace the old. These diseases include certain types of leukemia, disease producing bone marrow fibrosis or tumors. Severe injuries causing bleeding and subsequent shock naturally reduce granulocytes along with other types of blood cells.
Other causes of granulocytopenia include radiation and chemotrothorapia that can destroy healthy mature white blood cells or disrupt new cell formation. To this form of anemia can contribute a longList of over -the -counter prescription medicines, including non -steroidal anti -inflammatory and steroid drugs. Some antibiotics, antihypertensives and cardiac drugs have side effects that include a reduction in the number of granulocytes.
As the condition affects the concentrations of white blood cells that provide immunity, persons affected in general generally have a higher risk of infection. Symptoms of granulocytopenia include chronic or recurrent bacterial, fungal or viral infections. Individuals can experience low -degree fever, persistent gum pain, redness or swelling or skin abscesses. Patients also commonly tolerate swollen uterine glands, sinus infections and ears along with bronchitis or pneumonia.
In severe cases, individuals develop enlarged spleen and show petechial bleeding, which appear as a red-red spots on the body. In some cases, granulocytopenia may be treatable after the determination of the basic cause. Healthcare providers if they areBeni infections, usually prescribe antimicrobial drugs. If drugs are the cause, the problem may correct the dose adjustment.