What Is Mesenchymal Chondrosarcoma?
Mesenchymal chondrosarcoma is a rare malignant chondrosarcoma that occurs in young adults. The first case originated from mesenchymal chondrosarcoma of soft tissue.
- nickname
- Mesenchymal chondrosarcoma
- Visiting department
- orthopedics
- Multiple groups
- Young adults
- Common symptoms
- Pain, swelling, lump and joint stiffness
Basic Information
Causes of mesenchymal chondrosarcoma
- Most originate from bone tissue, and a few originate from soft tissue. Dense round cell proliferation, like Ewing's sarcoma, lymphoma, and hemangiopericytoma. The cells are round or oval, these small cells have hemangiopericytoma-like or vesicular-like structures, and there are large or small cartilage islands in the tissue. These cartilage-like areas may have no malignant characteristics and often tend to calcify Ossification.
Clinical manifestations of mesenchymal chondrosarcoma
- Pain, swelling, lumps and joint stiffness that last for months to years are the main clinical symptoms of the tumor. The invasive bones were the pelvis, femur, humerus, vertebra, mandible and skull. Occasionally, periosteal and skeletal polycentric tumors have been reported. Extraskeletal tissues are mainly affected by the meninges, lower limbs, and orbits. The radiological changes of tumors are mainly manifested by irregular borders of soft tissue ossification, erosive bone destruction, osteosclerosis, periostitis, and central calcification. The radiological appearance of the tumor is similar to that of general chondrosarcoma. The tumors vary in size, can be lobulated in shape, and have fibrous membranes on the surface. Histologically, the tumor is characterized by a mixture of hyaline cartilage islands and malignant small cells. Most of the tumors originate from bone tissue, and a few originate from soft tissue.
Mesenchymal chondrosarcoma examination
- X-ray showed osteolytic lesions, penetrated and damaged cortical bone, and tumors often had blurred calcifications.
Diagnosis of mesenchymal chondrosarcoma
- Diagnosis can be made based on the cause, clinical manifestations, and laboratory tests.
Mesenchymal chondrosarcoma treatment
- Radical surgical resection is the main method for treating mesenchymal chondrosarcoma. Radiotherapy and / or chemotherapy are the main measures for non-surgical treatment, but there is no obvious positive effect. Locally sufficient radical treatment is of great significance to prevent recurrence and distant metastasis. For resectable pelvic, tibia, and proximal femoral tumors, surgical resection and adjuvant radiotherapy are available. Non-surgical treatment, especially small cell tumors, can be combined with chemotherapy and radiotherapy similar to small cell sarcoma. Combined chemotherapy for recurrent tumors is better than single-dose chemotherapy.