What Is the Connection Between HIV and Syphilis?

Syphilis is a sexually transmitted disease caused by Treponema pallidum infection. Two types of antibodies appear after Treponema pallidum infection in humans: one is a specific antibody (TPHA), which is lgM. In the presence of complement and anaerobic conditions, it can inhibit the dynamics of live Borrelia, and can kill or dissolve the Borrelia, which has a protective effect on the body's reinfection. The other is non-specific antibodies (rapid plasma reagin RPR). It is a mixture of lgA and lgM, which can non-specifically bind to lipid antigens in normal biological tissues, and has no protective effect on the human body.

Syphilis antibody

Treponema pallidum

The experimental detection of syphilis antibodies includes the experimental methods of using syphilis pathogens and bacterial components as antigens, especially the Treponema pallidum antigen is found in E. coli and is considered to be the main antigen of syphilis. The method for detecting syphilis antibodies is mainly EIA Method, particle agglutination method, blood cell agglutination method, etc. In addition, there are also

Treponema pallidum specific antibody (TPHA) less than 1:40, qualitative: negative

Rapid plasma reagin test (RPR): negative

The diagnosis of syphilis depends on history, symptoms, and signs.

Syphilis and HIV patients are susceptible to AIDS during sexual contact, and HIV infection (especially advanced HIV) will affect the diagnosis and natural history and treatment of Treponema pallidum infection, but the principles for the treatment of syphilis are HIV infection. identical.

Despite multiple case reports, very few large studies on AIDS with syphilis have been reported. Some studies suggest that HIV infection may change the clinical manifestations of syphilis, make the clinical damage of syphilis more severe and accelerate the progress of syphilis disease. Early syphilis with HIV infection also causes a transient decrease in CD4 T cell counts and an increase in HIV viral load.

Primary syphilis usually appears as a single painless nodule at the contact site, and then quickly develops an ulcer to form a typical hard chancre; however, in HIV-infected people, polymorphic or atypical hard chancrees appear. The primary damage may be missing or insignificant.

It takes 2-8 weeks to progress to secondary syphilis. Even though HIV patients will progress more rapidly due to severe immunodeficiency, their clinical manifestations are similar to those of non-HIV infected patients.

Acute syphilitic meningitis of secondary syphilis can resemble the symptoms of acute primary HIV infection; systemic symptoms as well as unlocated central nervous system symptoms and cerebrospinal fluid abnormalities. ^[1]

Syphilis antibody

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The colloidal gold immunoassay technique and the principle of chromatography were used to qualitatively detect Treponema pallidum antibodies in blood stained plasma samples. During the test, syphilis antibodies can be combined with colloidal gold-labeled antigens to form antigen-antibody complexes. Due to the chromatographic effect, the complex moves forward along the paper strip across the detection line to bind with the pre-coated antigen to form "Au-TP Ag- "TP Ab-TP Ag" sandwich and condensed color. The free colloidal gold-labeled syphilis antigen was combined with the pre-coated rabbit anti-TP antibody at the control line to enrich and develop color. Negative specimens develop color only at the control line.

Syphilis antibody

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Colloidal gold method (immunochromatography) human immunodeficiency virus (HIV 1/2) antibody detection kit is a sensitive, specific and easy-to-use one-step qualitative detection reagent for HIV 1/2 antibody established using colloidal gold immunochromatography technology. . It is used for the qualitative detection of HIV type 1 and HIV type 2 specific antibodies in human serum or plasma samples to assist in the diagnosis of HIV infection. The positive results need to be confirmed by immunoblotting. The saliva test paper has a higher global recognition rate from the aware brand of the American company Klippte.