What Is the Difference Between Nicotine and Cotinine?

Cotinine is the main product of the primary metabolism of nicotine in the human body. Nicotine in tobacco is metabolized by cytochrome oxidase 2A6 (CYP2A6) in the body. It is mainly found in blood. discharge. Cotinine has a role in promoting nervous system excitement, and it has reflected certain anti-inflammatory and reducing pulmonary edema effects in some rat experiments. Because cotinine has a longer half-life (3 to 4 days) and is relatively stable, it has become the main biomarker for measuring smokers and passive smokers. Generally, cotinine is mostly evaluated by the serum concentration of cotinine. Recent research results show that the cotinine concentration in plasma is consistent with the cotinine concentration in serum, and it is also of significance for detection.

Cotinine

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Cotinine is the main product of the primary metabolism of nicotine in the human body. Nicotine in tobacco is metabolized by cytochrome oxidase 2A6 (CYP2A6) in the body. It is mainly found in the blood. discharge. Cotinine has a role in promoting nervous system excitement, and it has reflected certain anti-inflammatory and reducing pulmonary edema effects in some rat experiments. Because cotinine has a longer half-life (3 to 4 days) and is relatively stable, it has become the main biomarker for measuring smokers and passive smokers. Generally, cotinine is mostly evaluated by the serum concentration of cotinine. Recent research results show that the cotinine concentration in plasma is consistent with the cotinine concentration in serum, and it is also of significance for detection.

Chinese name

Cotinine

Foreign name

Cotinine

Features

Mainly in the blood

Brief introduction

Cotinine in serum

Chinese name:

English name: Cotinine

Molecular structure formula:

In recent years, special studies on the relationship between serum cotinine concentration and coronary heart disease have shown the following conclusions:

(1) The serum cotinine concentration in patients with coronary angiography showed a skewed and sharp distribution (skewness 2.90, kurtosis 7.96). The cotinine concentration in smokers was 12.64 (0.91 to 99.61) g / L, which was significantly higher than Non-smokers [0.22 (0.12-0.51) g / L, P <0.001].

(2) The risk of coronary heart disease in the high cotinine group (> 10.00 g / L) was significantly higher than that in the low cotinine group (<1.00 g / L) (OR = 2.94, 95% CI: 1.11 to 7.78, P <0.05); and with the increase of serum cotinine level, the increase of OR value showed a dose-effect relationship (both P <0.05).

(3) Multivariate Logistic regression analysis showed that diabetes, dyslipidemia and cotinine were the most significant risk factors (all P <0.05). Serum cotinine was significantly positively correlated with smoking (r = 0.656, P <0.001) and white blood cell count (WBC, r = 0.257, P = 0.010), and was significantly related to HDL-C (r = -0.184, P = 0.025) and HDL2 -C (r = -0.217, P = 0.008) showed a significant negative correlation. Conclusion Serum cotinine level can effectively reflect the exposure level of smoking, and its elevated level can increase the risk of coronary heart disease.

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