What is the relationship between apoptosis and cancer?

The programmed death of the cell is called apoptosis, an event usually caused by internal damage or signals from the surrounding tissues. Apoptosis and cancer are connected by two important ways. First, tumors cannot grow if the normal safety system in the body detects and causes their self -destruction, so cancer often block mechanisms that the body indicates uncontrolled tissue growth for apoptosis. Second, cancer cells inactivate genes that code the necessary proteins to destroy malignant cells. Chemotherapy uses the relationship between apoptosis and cancer damage to tumors and their designation to death.

Apoptosis occurs when chemical signals initiate the process of self -destruction in the cell, through changes in the membrane, degradation of DNA in the core and digestion of cell proteins by specialized enzymes. There are two types of paths that cause the cell to undergo apoptosis: an inner that is initiated by DNA and external submutation, which takes its allusions from the outside of the cell. The outer road can be triggeredHormones, toxins and other molecules capable of activating a special placement on a cell known as death receptors.

During the early stages of tumor formation, mutations in DNA, which change the relationship between apoptosis and cancer that allow uncontrolled cell growth. Cancer includes pathological changes in the cycle by which cells reproduce and proliferate, events that usually cause apoptosis when detected in healthy cells. This is sometimes done by suppressing gene coding for important proteins that the body uses to signal cancer tissues to eliminate apoptosis. Tumors can also eliminate chemical messengers who are squeezing or blocking a process that would usually order cancer cells to undergo self -destruction.

And the important gene, P53, encodes Messenger proteins that cause apoptosis. Some cancers caused by viruses suppress the activation of this gene and cause tumor cells to lessThey respond to the activation of death receptors. Whether it is caused by viruses or not, in tumors, cellular production of substances increasing growth increases. Normally, the body responds to uncontrolled proliferation of a particular type of cells by causing weight apoptosis, but during oncogenesis - cancer formation - balance between apoptosis and cancer, skew towards cell growth, not death.

Chemotherapeutic treatment often depends on the relationship between apoptosis and cancer. Most of these drugs also interfere with DNA synthesis and cell division or growth, but these mechanisms ultimately work on the destruction of tumor cells before they are divided and produced more copies of themselves. Different drugs activate different points along the road, which also leads to programmed cell death, sometimes, sometimes by raising the sensitivity of death receptors on tumor cells. Since some malignancies no longer respond to self -destruction signals, scientists are interested in the development of chemotherapies that can directly cause natural apoptose events.