Is it safe to combine diclofenac and alcohol?

Diclofenac is a painkiller that is in a drug class called non -steroidal anti -inflammatory drugs (NSAIDs). This medicine is sometimes sold to an over -the -counter (OTC), but although both Diklofenac and alcohol are widely available, they are not entirely safe to combine. Many NSAIDs are not safe to combine with alcohol because of the way these drugs develop their effects on the human body. NSAID as Diclofenac prevents the functioning of COX-2, which prevents inflammation. They also prevent the work of a structurally similar enzyme known as Cox-1. Cox-1 usually plays a role in the protection of gastrointestinal (GI) from stomach acids. Sufficient doses of this drug can therefore leave the stomach more open for damage for digestive acid. Together, diclofenac and alcohol can cause more damage than one substance taken by itself. One combination of these two may not lead to permanent damage, but large doses of one substance, their joining for a long time or often combining them together can damage the stomach and intestines.

stomach bleeding and ulcers may result from repeated mixing of diclofenac and alcohol. Sufficient bleeding can sometimes lead to loss of blood stomach and anemia, a weakened state caused by loss of blood and nutrients. In addition, long -term tissue damage may develop, weaken the stomach and more easily damage in the future.

This damage is considered to be caused by diclofenac and alcohol preventing the formation of greasy molecules called prostoglandins, which help regulate the contractions of the stomach muscle. Cox enzyme trigger creating prostoglandins under normal conditions, but this action is prevented by Diclofenac. Alcohol can directly damage the stomach tissue, which cannot be repaired without active coox enzymes.

scientists have evaluated a combination of diclofenac and alcohol as a mild risk. It probably does not cause occasional mixing of small amounts of these compounds unless an individual is particularly CITent to their effects. Repeated combinations of these substances and a high dose mixture can increase the potential damage they can cause. In extreme cases, bleeding may result from this mixture to death. Bloody stools, stomach pain and heartburn are a sign of damage to this combination and patients experiencing these symptoms are usually recommended to consult a doctor.