What Are the Signs of a Quetiapine Overdose?

Quetiapine is a neurological drug used to treat schizophrenia.

Quetiapine

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Quetiapine is a neurological drug used to treat schizophrenia.

Drug Name

Quetiapine

Alias

Quetiapine; Enric; Qiwei; Dalixin; Quetiapine fumarate; Quetepine; Sexoquel

Foreign name

Quetiapine

Main indications

Treatment of schizophrenia

Quetiapine

Quetiapine

Quetiapine; Seroque; Qiwei; Dalixin; Quetiapine fumarate; Quetepine; Sexoquel

Neurological Drugs> Antipsychotics, Antidepressants, Anxiolytics> Other

25mg, 50mg, 100mg, 200mg.

Quetiapine belongs to the atypical antipsychotic class of dibenzoxazepines. It has affinity for 5-HT, dopamine D2, histamine, and H1- and 1-, 2-receptors.

Quetiapine is easily absorbed after oral administration and is widely distributed throughout the body. The protein binding rate was 83%. Extensive metabolism in the liver is mainly through sulfoxidation mediated by P450CYP3A4, but also through oxidation. It is mainly excreted as inactive metabolites, and about 75% of the dosage appears in urine, and 20% of them are found in feces. Elimination of tl / 2 is about 6-7 hours.

Treatment of schizophrenia.

Allergic to quetiapine is prohibited.

1. Not yet evaluated. Animal experiments show that it has an impact on the fetus, and pregnant women should use it with caution. It is unclear whether quetiapine is excreted through milk, and women taking quetiapine should not breastfeed.

2. Symptoms and treatment caused by drug overdose: In clinical experiments, there is not much experience with this drug overdose. Some people have taken more than 10g of the drug without causing death, and the patient recovered completely without sequelae. In general, the reported symptoms and signs are enhancements of the drug's known pharmacological effects, namely drowsiness and sedation, palpitations and hypotension. Quetiapine has no specific antidote. Patients with severe poisoning should consider the possibility of multiple drug interventions and recommend active monitoring measures, including opening a good airway, ensuring proper oxygen supply and breathing, and Monitor and maintain cardiovascular system function. Close medical monitoring and monitoring should be taken until the patient recovers.

3. Do you need to adjust the dose for liver and kidney insufficiency: The clearance rate after oral quetiapine decreases in patients with kidney and liver damage by about 25%, quetiapine is widely metabolized in liver and kidney, so it should be used with caution In patients with damage, patients with kidney or liver damage, the starting dose should be 25 mg per day, and the dose should be increased on the following day, ranging from 25 to 50 mg, until the effective dose.

1. See chlorpromazine.

2. The most common is drowsiness.

3. Extrapyramidal reactions with low incidence.

4. Prolactin concentration may be lower than chlorpromazine.

5. Others include weakness, anxiety, myalgia, rhinitis, anorexia, increased cholesterol and triglyceride concentrations, and decreased thyroid hormone concentrations.

6. Patients with long-term use of quetiapine have asymptomatic crystal changes. Animal (dog) tests have confirmed that cataracts have been present over time.

1. Oral 25mg, 2 times a day, 50mg on the second day, 2 times a day, 100mg on the 3rd day, 2 times a day, 150mg on the 4th day, 2 times a day. Then adjust the dosage according to the effect, the general dosage range is 300-450mg per day, divided into two doses. While some patients have achieved a satisfactory level of efficacy by taking 150 mg orally per day, others must take the maximum dose of 750 mg per day.

2. The elderly and those with liver and kidney dysfunction should reduce the dose, starting at 25mg per day, and gradually increasing the dose by 25-50mg according to the effect.

1. See chlorpromazine.

2. Thiolidazine can increase the elimination of quetiapine.

3. The inducers or inhibitors of CYP3A4 can change the metabolism of quetiapine and increase or decrease the plasma concentration.

Quetiapine is an atypical antipsychotic that interacts with multiple neurotransmitter receptors. Mainly used for schizophrenia. Oral absorption is good, metabolism is complete, its effective dose may be lower than ordinary people, the safety of use is the same as other antipsychotics, and it should be used with caution in the elderly.