What Is Fibrin Glue?

This product is mainly composed of fibrinogen (containing coagulation factor XIII, fibronectin and appropriate aprotinin) and thrombin concentrate prepared from human plasma. When the two components are mixed, the final step of the coagulation chain reaction is simulated. Through the activation of fibrinogen by thrombin, the fibrinogen is gradually polymerized, and finally a fibrin solidified substance is formed, which plays a role of hemostasis and tissue adhesion before and after surgery.

Fibrin glue

This entry lacks an overview map . Supplementing related content makes the entry more complete and can be upgraded quickly. Come on!

This product is mainly composed of fibrinogen (containing coagulation factor XIII, fibronectin and appropriate aprotinin) and thrombin concentrate prepared from human plasma. When the two components are mixed, the final step of the coagulation chain reaction is simulated. Through the activation of fibrinogen by thrombin, the fibrinogen is gradually polymerized, and finally a fibrin solidified substance is formed, which plays a role of hemostasis and tissue adhesion before and after surgery.

Chinese name

Fibrin glue

Foreign name

Fibrin Glue

Alias

Fibrin glue, fibrin glue, Compxin

Precautions

Pregnant and lactating women should be cautious when taking medication

Fibrin Glue ^[1]

Fibrin Adhesive, Fibrin Adhesive, Compex, Fibrin Sealing System, Fibrin Sealant (Human) for Surgery, FG, Fibrin-fibronectin sealing system, FFSS

Human fibrin glue: 1.0ml; 2.0ml; 5.0ml

Auxiliary treatment for local hemostasis in burns and general surgery.

Known to be highly sensitive to bovine protein.

1. Pregnant and lactating women should be used with extreme caution. 2. Intravenous administration of this product is strictly prohibited and is for local use only. 3 The prepared solution is used within 4h. 4 Avoid contact with alcohol, iodine or other heavy metals in the disinfectant to avoid causing denaturation. All impurities on the surface of the wound should be removed before applying the two ingredients. 5. The excess drug is rapidly hydrolyzed and absorbed by its own plasmin within about 15 days. 6. Unintentional intravenous use may cause thrombotic complications, so intravenous use is strictly prohibited. Severe arterial and venous bleeding requires additional measures. 7. Please use the syringe and injection needle provided with this product to dissolve and aspirate the corresponding products and solutions respectively. The apparatus for preparing fibrinogen solution must not be mixed with the apparatus for preparing thrombin solution, so as to avoid gel formation in advance. 8. When dissolving lyophilized human fibrinogen, first equilibrate the temperature of the product and its dissolving solution to 30-37 ° C. After injecting the dissolving solution, let it stand for 1-2 minutes, and then gently rotate it until the lyophilized preparation is completely dissolved to avoid dissolution. Foaming. 9. Connect the two syringes and injection needles firmly with the connection needle holder. 10 During use, if you find that the injection needle or nozzle is blocked by a protein clot, replace it with a new injection needle or nozzle. Once the colloid has begun to be delivered, the needle plunger cannot be pulled back, otherwise the colloid will return to the "Y" -shaped converter, which will block the tip of the applicator and need to open a new "Y" -shaped converter. 11.2 8 Keep away from light for storage and transportation. Freezing is strictly prohibited.

Allergic reactions may occur in patients who are highly sensitive to bovine protein or under repeated use conditions. If symptoms occur, medication should be stopped immediately. Antihistamines and corticosteroids can be injected if the reaction is severe and needs treatment. If anaphylactic shock is found, epinephrine (slow intravenous injection) should be injected immediately, and an increased dose of corticosteroids (slow intravenous injection) should be used to restore blood volume.

Use a syringe to aspirate the lyophilized human fibrinogen solution and inject it into a lyophilized human fibrinogen bottle to obtain a lyophilized human fibrinogen solution; use another syringe to aspirate the lyophilized human thrombin solution and inject the lyophilized human Inside the thrombin bottle, a lyophilized human thrombin solution was obtained. Use the original syringe to aspirate the lyophilized human fibrinogen solution and lyophilized human thrombin solution, etc., and then snap them into the pusher rack respectively, and then install the injection needle seat or nozzle to the cone head connected to the needle seat , The two syringe cones are firmly connected to the connection needle seat. After installation, check that there are no loose leaks, push the syringe linkage evenly and evenly, and apply cloth or spray to the tissue wound surface to be treated to form fibrin glue. Before applying gel, dry the wound surface to provide a dry surface, and then apply glue along the suture or wound surface, and it will begin to solidify within 10 seconds. After applying the gel, do not blot dry or compress the wound for at least 60s. The dosage used is related to the surface to be adhered or covered, and the method of application. The 1.0ml-specific surgical freeze-dried human fibrin glue can be used to adhere to a wound area of about 10 cm2.