What Is Gallium Nitrate?

Gallium nitrate, the drug name, has a certain effect on lymphomas and tumors, non-small cell lung cancers and tumors. When used together with other potentially intoxicating kidney drugs such as aminoglycosides and amphotericin, it may increase the risk of sub-severe renal insufficiency, so it should be avoided at the same time and strengthened hydration.

Chinese name: Gallium Nitrate

Dissolve gallium metal or gallium trioxide in nitric acid. The solution was evaporated and concentrated and water was added. This operation was repeated until no nitric acid odor was present in the concentrated solution. Then diluted with water to make 26 g of gallium per 100 mL of solution. Ga (NO ₃ ) ₃ · xH ₂ O can be precipitated by cooling the viscous solution. After suction filtration, the obtained crystal was dried under vacuum at room temperature, and then dried at 40 ° C. for 48 h to obtain an anhydrous substance. ^[1]

Toxicity data from literature and journals

Numbering	Toxicity type	testing method	Test object	Dosage used	Toxic effect
1	Acute toxicity	Intravenous injection	Humanity	7 mg / kg	1. Gastrointestinal toxicity-nausea, vomiting 2. Kidney, ureter and bladder toxicity-Decreased renal function 3. Kidney, ureter and bladder toxicity-proteinuria
2	Acute toxicity	Intravenous injection	Humanity	144 mg / kg	1. Hematological toxicity-Orthocytic anemia 2. Hematological toxicity-Thrombocytopenia
3	Acute toxicity	oral	Mouse	4360 mg / kg	1. Peripheral neurotoxicity-flaccid paralysis without anesthesia (usually neuromuscular block) 2. Behavioral toxicity-lethargy 3. Behavioral toxicity-affect food intake (animals)
4	Acute toxicity	Intraperitoneal injection	Mouse	500 mg / kg	Detailed effects are not reported other than lethal dose
5	Acute toxicity	Subcutaneous injection	Mouse	600 mg / kg	1. Peripheral neurotoxicity-flaccid paralysis without anesthesia (usually neuromuscular block) 2. Behavioral toxicity-lethargy 3. Behavioral toxicity-affect food intake (animals)
6	Acute toxicity	Intravenous injection	Mouse	55 mg / kg	1. Behavioral toxicity-anorexia 2. Lung, chest or respiratory toxicity-acute pulmonary edema 3. Gastrointestinal toxicity-excessive exercise, diarrhea
7	Chronic toxicity	Intraperitoneal injection	Rat	500 mg / kg / 10D-I	1. Lung, chest or respiratory toxicity-pulmonary interstitial fibrosis, lung disease (including pneumoconiosis) 2. Lung, chest or respiratory toxicity-pleural effusion 3. Chronic disease-related toxicity-death
8	Chronic toxicity	Intraperitoneal injection	Rat	70 mg / kg / 7D-I	1. Skeletal muscle toxicity-other changes 2. Nutrition and metabolic system toxicity-weight loss or rate of weight loss
9	Chronic toxicity	Intraperitoneal injection	Mouse	750 mg / kg / 10D-I	1. Lung, chest or respiratory toxicity-pulmonary interstitial fibrosis, lung disease (including pneumoconiosis) 2. Kidney, ureter and bladder toxicity-changes in renal tubules (including acute renal failure, acute tubular necrosis) 3. Chronic disease-related toxicity-death
10	Chronic toxicity	Subcutaneous injection	Mouse	880 mg / kg / 13W-I	1. Skeletal muscle toxicity-other changes 2. Nutrition and metabolic system toxicity-weight loss or rate of weight loss
11	Ocular toxicity	Skin surface	mammal	500 mg	Serious effect
12	Mutation toxicity		Mouse leukocytes	100 umol / L
13	Mutation toxicity		Mammalian lymphocyte	40 umol / L

^[2-10]

Overview of emergencies: may increase combustion; oxidants. Causes skin irritation. Causes severe eye irritation.

GHS risk categories:

Oxidizing solids category 2

Skin corrosion / irritation category 2

Severe eye damage / eye irritation category 2

Signal Word: Danger

Hazard statement:

H272 May intensify fire; oxidant.

H315 Causes skin irritation.

H319 Causes serious eye irritation.

Precautionary statement:

Precaution:

Keep P210 away from heat / sparks / open flames / hot surfaces. No smoking.

P220 Keep away from clothing / flammable materials.

P280 Wear protective gloves / protective clothing / eye protection / face protection.

P264 Wash thoroughly after handling.

Incident response:

P370 + P378 In case of fire: Use fire extinguisher to extinguish.

P302 + P352 IF ON SKIN: Wash thoroughly with water.

P332 + P313 If skin irritation occurs: Get medical advice / attention.

P362 + P364 Take off contaminated clothes and wash before reuse

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. If you can wear contact lenses, you can easily remove them. Continue flushing.

P337 + P313 If eye irritation persists: Get medical advice / attention.

Disposal: P501 Dispose of contents / container in accordance with local regulations.

Physical and chemical hazards: May worsen combustion; oxidants.

Health hazard: Causes skin irritation. Causes severe eye irritation. ^[1]