What Is Influenza Neuraminidase?

Neuraminidase, also known as sialidase, is a glycoprotein distributed on the envelope of influenza virus. It has antigenicity and can catalyze the hydrolysis of sialic acid. It helps mature influenza virus to escape from host cells and infect new cells. Played an important role in the cycle. In influenza A virus, the neuraminidase antigenicity will change, which becomes the basis for classifying influenza A virus subtypes. There are 9 different neuraminidase antigens in the currently known influenza A viruses. type.

Neuraminidase

The neuraminidase distributed on the surface of the influenza virus envelope is a tetramer composed of four identical monomeric subunits. Each of the two subunits is linked to each other through a disulfide bond. Monomers are four monomers that make up a tetramer. Each monomer consists of a spherical head and an elongated neck. The head is neuraminidase.

Neuraminidase tetramer ribbon model neuraminidase is responsible for catalysis

Neuraminidase is one of the targets for the treatment of influenza. Since humans understand the role of the enzyme,

Hemagglutinin

Sialic acid

Oseltamivir

Zanamivir