What is moxonidine?

Moxonidine is an antihypertensive, a drug prescribed for lower high blood pressure. It reduces the activation of the sympathetic nervous system, reduces the blood vessel resistance and thus the workload of the heart. In addition to its effects on blood pressure, moxonidine has been shown to reduce insulin resistance and increase glucose metabolism that can help prevent cardiovascular diseases. Like other centrally acting antihypertensive substances, alternative types of drugs do not work or cannot be given to the patient because of health considerations.

is one of the ways of the sympathetic nervous system controls blood pressure, is increased vascular resistance and heart dispensing, so the reduction of these effects is a method of treatment of hypertension. In the brain, A2 receptors for neperepinephrine, when activated, reduce the effects of the sympathetic nervous system and lower vascular resistance, which reduces blood pressure. The protein group forms the subclass A2S are imidazoline receptors. Several antihypertsEncative drugs, including clonidin and moxonidine, work through a link to A2 receptors and their activation. Unlike clonidine, moxonidine is specific in binding to imidazole receptors, which is more selective.

Protože pracuje přímo na mozkových fyziologických regulačních centrech, je monoxidin klasifikován jako centrálně působící antihypertenzivní lék. Usually, diuretics or inhibitors of ACE, followed by beta blockers, first prescribed to patients with hypertensive patients in front of centrally acting substances to which the treatment of the ministry only if these other drugs have failed or cannot be safely administered. It looks just as effective compared to similar substances as clonidine, directly on the central nervous system. Reduction of blood pressure in patients taking this medicine was up to 20%.

insulin resistance syndrome, factors complex, including reduced SCHopness metabolize glucose and excess abdominal fat, correlates with an increased risk of cardiovascular disease. In various laboratory tests it has been shown that moxonidine increases insulin sensitivity and improves cellular glucose cooling, which are both important factors in health protection. It also reduced weight gain and reduced lipid system levels in test animals. Similar studies of kidney failure indicated that the drug protected the drug from further renal damage.

normally prescribed by adults according to the level of hypertension, moxonidine is not recommended in patients with heart conditions including hypotension or circulatory problems, as it could worsen these symptoms. It is usually not prescribed to those who have kidney disease or are administered along with the thiazide class diuretic drugs, which could cause hypotension in combination with another drug with similar effects. This should be noted that in clinical trials moxonidine had less side effects than clonidesn.

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