What is the pergolas?
Pergolide is an ergot derivative commonly used to treat Parkinson's disease. Patients can take medication separately or in conjunction with a combination of levodopa/carbidopa. Parkinson's drugs are associated with multisystem side effects, including damage to the heart valve. It was withdrawn from the US market due to a large number of patients who experienced this serious undesirable reaction.
Anti-Parkinson's effects of pergolide occur when the drug connects to synaptic dopamine receptors in the brain. The binding stimulates dopamine production in nigrostriatal pathways. It is a loss of dopamine from these paths that produce the pathological features of Parkinson. The drug also inhibits the secretion of prolactin, causes temporary growth of growth hormone and temporarily lowers the levels of luteinzing hormone.
In addition to Parkinson's disease, pergolide can be prescribed as a treatment for hyperprolactinemia or restless legs. Parkinson's patients taking medication along with dopamine substitutes may be hungryINY dopamine increased by up to 30%. The effect of agonist dopamine receptor formulation may allow some patients to reduce or interrupt other medicines.
After entering the body, 90% of the pergolide binds to the proteins and this effect may disrupt other drug -binding drugs. Pergolide should not be used in combination with dopamine antagonists, because drugs generally inactive. Drugs are also bound to certain cell receptor cells placed throughout the body and create a number of adverse effects.
Pergolide can cause postural hypotension and peripheral edema and patients may also experience premature atrial contractions or sinus tachycardia. The heart valve was damaged due to inflammatory responses or fibrosis. This side effects can also contribute to pleuritis, pleural effusion and pneumonia. The common side effects of the airways also include runny nose and cough.
serious reactions centralThe nervous system involves falling asleep without having a previous feeling of drowsiness. This effect becomes potentially dangerous when individuals using pergolide operate motor vehicles or mechanical devices. Patients also complain about experiencing confusion, double vision and hallucinations.
Some individuals show dyskinesia, a condition associated with involuntary recurring movements. People with dyskinesia can show a constant slap on the lips or seemed to throw a pill between the thumb and the index finger. The condition can also produce a constant flashing, protrusion of language or walking with scrambled walking.
individuals using pergolide on prescription usually experience diarrhea or constipation and nausea along with discomfort of the abdomen. Many complain about generals as discomfort accompanying arthritis. There may also be a sudden increment and loss due to swelling.