What Is the Difference Between Epinephrine and Atropine?

Atropine blocks M-choline receptors, relaxes the sphincter and ciliary muscles of the pupils, leading to the function of the pupil-expanding muscles dominated by noradrenergic nerves, thereby dilated pupils. The dilated pupil pushes the iris toward the corneal corner of the iris, preventing the aqueous humor from draining through the trabecular meshwork into the scleral sinus, causing an increase in intraocular pressure. Atropine relaxes the ciliary muscles, tightens the ligament to flatten the lens, reduces its diopter, and causes adjustment paralysis. It is in a state where the distant object is clear and the near object is blurred.

Atropine eye cream

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Atropine blocks M-choline receptors, relaxes the sphincter and ciliary muscles of the pupils, leading to the function of the pupil-expanding muscles dominated by noradrenergic nerves, thereby dilated pupils. The dilated pupil pushes the iris toward the corneal corner of the iris, preventing the aqueous humor from draining through the trabecular meshwork into the scleral sinus, causing an increase in intraocular pressure. Atropine relaxes the ciliary muscles, tightens the ligament to flatten the lens, reduces its diopter, and causes adjustment paralysis. It is in a state where the distant object is clear and the near object is blurred.

Chinese name

Atropine eye cream

Main ingredients

atropine

Dosage and usage

Three times a day, apply to eyelids

English name: Atropine Sulfate Eye Ointment

Main ingredients: Atropine.

Chemical name: - (hydroxymethyl) phenylacetic acid 8-methyl-8-azabicyclo [3.2.1] -3-octyl sulfate-hydrate.

Interest molecular formula: (C17H23NO3) 2 · H2SO4 · H2O.

Molecular weight: 694.84.

Properties: This product is light yellow ointment.

Pharmacokinetics: Atropine causes dilated pupils and ciliary muscle paralysis. The onset time is 30 minutes and lasts 12 to 14 days. This product can be absorbed through the conjunctiva of the eye. Oral absorption of atropine is rapid. The blood concentration reaches a peak after 1 hour, the bioavailability is 50%, the half-life (t1 / 2) is 4 hours, and the effect is maintained for about 3-4 hours. Immediately after absorption, it leaves the blood and distributes throughout the body tissues. It can penetrate the blood-brain barrier and also enter the fetal circulation through the placenta.

Indications: For dilated pupils, it can also be used for iridocyclitis.

Dosage and Administration: Apply three times a day to the eyelids.

Adverse reactions:

1. Eye medication may cause blurred vision, transient ocular burning and stinging, photophobia, and dry mouth, dry skin and mucous membranes, fever, facial flushing, and tachycardia due to systemic absorption.

2. A few patients have allergies such as itching, redness, and conjunctival congestion in the eyelids, and the drug should be stopped immediately.

Contraindications: Banned from:

1. glaucoma.

2. Enlarged prostate.

3 Brain trauma in children.

4 Down syndrome.

5. Spastic paralysis.

6. People who are allergic to this product.

1. Atropine pupil dilatation drugs have no significant effect on normal intraocular pressure, but for patients with abnormal intraocular pressure or narrow-angle, shallow anterior chamber eyes, the intraocular pressure can be significantly increased after application, and there is a risk of stimulating glaucoma. Therefore, atropine eye drops should not be used for such cases and patients over 40 years of age.

2. Allergic eyelid reactions or contact dermatitis should be discontinued immediately.

3 Use with caution in patients with corneal perforations or corneal ulcers who are about to perforate.

4 Vision is blurred after taking the medicine, especially when you are close to the object. At this time, you should avoid driving, using machines and performing any other dangerous activities.

5. After taking the medicine, the pupils are dizzy, and they can wear sunglasses in the sun and strong light.

Medication for pregnant and lactating women: Use with caution in pregnant women. Avoid using or stopping breastfeeding.

Medication for children: Use with caution and use a small amount.

Medication for elderly patients: disabled.

Drug interactions: Tricyclic antidepressants, H1-receptor blockers, anticholinergic antiparkinsonian drugs, phenothiazine antipsychotics, etc. all have anticholinergic effects, which can increase urine after combined use Atropine-like adverse reactions such as retention, constipation, and dry mouth. Drug overdose: Atropine lethal dose: about 80 to 130 mg for adults and about 10 mg for children. One 1% atropine sulfate eye ointment (2 g) contains a dose sufficient to poison 1-2 children. Therefore, eye ointments should be properly stored. In addition to measures such as gastric lavage, neostigmine, toxic lentiline or pilocarpine can be injected.

Specifications: eye ointment.

Manufacturer:

Whether Medicare medications: Medicare

Whether over-the-counter drugs: over-the-counter

Others: Avoid in patients with glaucoma.