What Are Cholinergic Receptors?

Cholinergic receptors (Acetylcholine receptors) can be divided into two types, which are the collective term for xun tone receptors and nicotinic receptors.

Cholinergic receptor

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Cholinergic receptors (Acetylcholine receptors) can be divided into two categories,

Cholinergic receptors have five subtypes

The central is mainly M1, M3, and M4 subtypes, and the peripheral nerves are mainly M1, M2, and M3 subtypes.

The amino acid primary structure of each isoform has 460 ~ 590 amino acid residues. The mechanism of action is coupling with G protein, activation of phospholipase C, and M receptor agonism can inhibit adenylate cyclase and activate K + channels or inhibit Ca2 + channels.

N Cholinergic receptor N-type cholinergic receptor

N receptors can be divided into two subtypes .

The receptors on the post-synaptic membrane of the ganglion neurons and the central N receptor are N1 receptors, and the quaternary ammonium hexahydrocarbons are blockers; the receptors on the skeletal muscle endplate membranes are N2 receptors, Blocker; Cyclops poison is a common blocker of N1 and N2.

N-type choline receptor is composed of 4 subunits (, , ,

) Consisting of 5-mers. These subunits are attracted to each other and surrounded by a channel-like structure, and two of the subunits are sites bound to acetylcholine. When acetylcholine and alpha subunit can open the ion channel, and thus regulate the flow of Na +, Ca2 +, K +. When the action potential reaches the end of the motor nerve, the presynaptic membrane is depolarized to cause cleavage efflux, and the acetylcholine is released to combine with the N receptor of the neuromuscular junction to generate a local depolarization potential, that is, endplate potential. When the endplate potential exceeds the muscle fiber spreading depolarization threshold, the voltage-gated ion channel on the membrane can be opened. At this time, a large amount of Na + and Ca2 + enters the cell, generating an action potential, resulting in muscle contraction.