What Are Pancreatic Enzymes?

Pancreatin is a digestive aid. It mainly contains trypsin, pancreatic amylase, and pancreatic lipase. Trypsin converts protein into peptone, pancreatic amylase converts starch into dextrin and sugar, and pancreatic lipase breaks down fat into glycerin and fatty acid. Strong activity under neutral or weak alkaline conditions. Digestion of starch, protein and fat in the intestinal fluid, thereby promoting digestion and appetite.

Basic Information

Drug Name

Trypsin

Foreign name

Pancreatin

Dosage form

Non preparation: API

Drug type

chemical

Trypsin indication

Mainly used for indigestion, loss of appetite, and digestive disorders caused by liver and pancreatic diseases.

Clinical application of trypsin

Oral: 0.3 0.6g / time, 3 times / day, before meals.

Trypsin Adverse Reaction

1. This medicine can cause cheek and perianal pain, bleeding in any part of the digestive tract, allergies or irritation causing respiratory symptoms (such as sneezing, tearing, rash, rhinitis and even asthma).

2. In patients with cystic fibrosis, the increase in uric acid in urine is seen when the drug is applied, and it is dose-related.

3. Occasionally diarrhea, constipation, upset stomach, nausea and rash.

Trypsin precautions

1. Pregnant women and lactating women should be used with caution.

2. This product is commonly used in oral enteric preparations to avoid acid inactivation, but the casing may affect the bioavailability of pancreatic enzymes in the upper duodenum and upper jejunum.

3. Do not chew when taking, so as not to leave the powder in the mouth, which will cause severe oral ulcers. This product should be discontinued for at least 3 days before pancreatic exocrine function determination.

4. Pancreatin has a slight odor but no putrid odor, and loses vitality when boiled or when exposed to acid.

Trypsin contraindications

Those who are allergic to this product are prohibited. Disable early patients with acute pancreatitis.

Trypsin Drug Interaction

1. Take with the same amount of sodium bicarbonate can increase the efficacy.

2. Cimetidine can inhibit gastric acid secretion and increase the pH value in the stomach and duodenum, so it can prevent the inactivation of pancreatic enzymes and enhance the efficacy of oral pancreatic enzymes. Because all H2 receptor antagonists can reduce gastric acidity, it is speculated that ranitidine, famotidine, nizatidine, etc. also have this interaction with pancreatic enzymes, and it may be necessary to reduce the amount of pancreatic enzymes when combined.

3. The activity of this product is weakened in acidic solution, and even decomposed and inactivated, so it should not be taken with acidic drugs.

4. When this product is used in combination with acarbose and miglitol, the latter's efficacy is reduced, so it should be avoided at the same time.

5. Trypsin can interfere with folic acid absorption, so patients taking trypsin may need to supplement folic acid.

Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.