What is IGF-1?
insulin growth factor 1 (IGF-1), sometimes called somatomedin C, is a hormone that promotes growth and prevents cellular death. It is structurally similar to insulin and also as insulin growth factor 2 (IGF-2). This hormone is used throughout the life of the human body, but becomes the most important during childhood and adolescence. Many animals-including mammals, birds and fish-k regulation of cell growth use IGF-1. It is produced in the liver, usually due to signals from growth hormone.
IGF-1 is bound to two types of receptors on the outer surface of the cell membranes: IGF-1 receptor (IGF1R) and insulin receptor. Both are members of the receptor tyrosinekinase (RTK) of class II. Pimars and unique effects of IGF-1 are carried out through IGF1R, which starts to activate a chemical sequence called the act of the path. This process, which revolves around a protein called an act, has significant effects on the life and death of the cell. IT seems to have an IGF-1 affects the inhibition of programmed cell death. This explains his bayA tranal role as a stimulus to grow tissue and as an accessory to cancer. This protein triggers a process that eventually causes the cell to occupy more glucose from the bloodstream. IGF-1 does not bind to the insulin receptor or activated as effectively as the insulin itself.
The effects of IGF-1 can be modulated by a series of six or seven proteins called proteins binding a growth factor similar to insulin (IGFBP). IGFBP-2 and IGFBP-5 inhibit its effects by preventing its binding to a cellular receptor. IGFBP-3, the most common of these proteins, extends the life of IGF molecules.
The excess of IGF-1 and IGF1R is associated with several types of diseases. Breast and prostate cancer may be caused by failure -related death associated with this chemical system. Gigantism and acromegaly, which causes unnatural growth and swelling in the body, can also be associated with the excess of this molecule. Because IGF-1 correlates with growth hormone, they canThis causes problems originally from excesses in growth hormone. Doctors suspect these conditions can measure IGF-1 for diagnostic purposes, as they usually also reflect the production of growth hormone.
Synthetic IGF-1, known as Mecasermin, is used as a treatment of lack of hormonal growth. Several different companies have tried to create and release versions of this drug with different levels of scientific and legal success. IGF-1 is also sold as a steroid for body building.