What is the connection between monocytes and macrophages?

both monocytes and macrophages are types of white blood cells that are part of the immune system. Monocytes are mostly found in the blood, while macrophages occur in tissues. Macrophages are created by monocyte differentiation. In most cases, the monocytes float in the bloodstream for up to three days before migration into specific tissue for differentiation of macrophages.

Monocytes are formed in the bone marrow and float free in the bloodstream. They have different roles depending on whether the body passes through the immune response or not. If there is no immune response, monocytes move to different tissues where they develop into macrophages and dendritic cells. In this case, the monocytes replace any macrophages they died. Monocytes can actively attack IGN in the bloodstream and tissues. Otherwise, they are distinguished into macrophages inside the tissue, so there are more of these types of cells to perform an immune response.

during the immune response of the body, monocytes and macrophages perform phagocytosis. In this process, cells are occupied by large particles. There are two reasons for phagocytosis to protect the body from harmful foreign molecules - or pathogens and get rid of damaged, dying and dead cells. In addition to performing phagocytosis, which gets rid of the body of pathogens, monocytes and macrophages have as part of the immune system: presentation of antigen and cytokine production.

The antigen presentation occurs when the parts of the pathogen that has been absorbed is displayed on the surface of monocytes and macrophages. The importance of the presentation of the IS antigen that it activates t cells so that they can recognize other molecules as foreign bodies in the future. This allows the immune system to respond faster when it comes into contact with foreign molecules that also have the structure of the protein of the antigen on their membranes.

cytokines are proteins that are used to signal other cells during cell communication. Makes a similar wayem as hormones and can stimulate and inhibit certain processes in cells. Common cytokines produced by monocytes and macrophages include the factor of tumor necrosis (TNF) and interleukins. TNF causes cellular death, while interleukins are involved in symptoms associated with inflammation, including fever.