What is pars compacta?

pars compacta is half of the nigra substantia, the area of ​​the midbrain near the brain stem. The primary function of PARS Compacta is the production of a neurotransmitter called dopamine. Dopamine concerns dependence, emotional reactions and movement. Exhaustion of dopamine can lead to Parkinson's disease and the excess could contribute to the onset of schizophrenia.

nigra nouns consists of a superior - or upper - pars compacta and lower - or lower - pars reticulata. Dendrites spread from the inside of the compacts that are engaged in production, into reticulatory, which focuses on transmission. The Pars compact is firmly full of tinted black cells of pigment neuromelanine.

These pigmented cells produce a neurotransmitter dopamine. Dopamine helps to transmit signals between neurons, promotes the production of other neurotransmitters and helps control the movement and feelings of reward, pleasure and pain. Dopamine in the pars compacta is transmitted by axoplasmic transport to other areas of the brain, especially caudate and putamen in the stretch.

cells containing melanin can degenerate, causing dopamine levels to fall to a point where other neurons can no longer help. It is not known what causes this degeneration, but the deficit created can lead to the onset of Parkinson's disease. Parkinson's disease is an incurable, weakening condition that causes trembling, rigid muscles and a gradual stopping of other movement functions.

Parkinson's disease options include the use of a pharmaceutical mixture of levodopy-carbidopa. Levodopa is in a class of drugs called central nerve agents and can pass through the blood -brain barrier and stimulate dopamine production in PARS Compacta. Dopamine antagonists are anusteria of drugs that can mimic the effects of dopamine in the receptor areas, allowing their function to continue. Neither class of drugs cannot cure the disease. The best that Parkinson's treatment can provide is a slowdown in contradictory dominionku.

It is assumed that excess dopamine can lead to schizophrenia. This proposal fulfilled some controversy in the medical field due to insufficient research data. However, patients who have schizophrenia show physiological differences in nigra nouns that indicate correlation between loss of dopamine and disease. Changes include pars compta showing a reduction in size in transmission terminals. Antipsychotics of the first generation used to treat symptoms of schizophrenia belonged to the class of dopamine antagonists.