What is the glucagonian peptide-1?
Maintaining the right blood sugar level is an essential function of a healthy body. The glucagon peptide-1 (GLP-1) is a molecule consisting of a short chain of 30 amino acids that helps the body in this process. This peptide hormone is primarily made in specialized intestinal cells called intestinal l cells. GLP-1 not only plays an important role in everyday functioning, but can also be useful as a basis for the treatment of diabetes. Initially, the glucagon peptide-1 is produced in an inert form called proglukagon. The active appearance is only available after part of the amino acid chain of the proglukagon that the cell breaks down.
As soon as these cells produce GLP-1 and release them into the bloodstream, this compound acts quickly to cause certain changes in the pancreatic cells. GLP-1 causes cells to produce insulin, hormone that causes cells to be used for energy for energy. In addition, glucagon peptide-1 determines cells from glucagon production, which is another hormone that takes place cells to UVOFlying sugars into the bloodstream. The pure effect of these effects is to reduce blood glucose levels and prevent the body from hyperglycemia, a condition caused by an excessive value of the circulating in the body.
Several other GLP-1 effects contribute to reducing blood glucose, including increasing the sensitivity of some insulin cells. It also promotes a feeling of fullness or satiety in the brain and prevents the stomach from discharging into the intestines. These actions also serve to reduce the total blood sugar levels, albeit an indirect way than actions supporting insulin production.
Monitoring of blood sugar and maintaining their stable is permanent activity that requires the ability to quickly respond to sudden changes. For this reason, the GLP-1 peptide has a simple compact structure that allows it to be easily created and degraded as needed. After excretion, the peptide-1-like glucagon is distributed by another enzymem in about two minutes. The short half -life of this peptide allows the body to respond to constant changes in glucose levels and prevents feedback from reducing blood glucose.
People with type II diabetes have less glucagon similar to peptide-1. Scientists believe that the actions of this peptide make it a useful starting point for the treatment of this disease. Clinical studies using an exendin compound that shows similar effects to GLP-1 has shown that it is effective in maintaining lower blood glucose levels.