What are conjugated antibodies?

conjugated antibodies are laboratory -produced compounds composed of antibodies combined with dyes, chemicals or proteins. These combinations of antibodies are used for research, testing and medical treatment. Companies that produce these antibodies commonly classify conjugations by means of marking, loading or marking that identify a substance attached to the antibody.

laboratories often create conjugated antibodies using fluorescent dyes. The antibodies marked with luminescent molecules absorb light, but emit the colors of one wavelength. These colors are visible under electron and fluorescent microscopes. Scientists use this method of designing antibodies for dyeing cells and tissue, sorting cells and blot immunoanalysis. Then these conjugated antibodies incubate with infected and non -infected cells. If the patient has antibodies to a specific microbial antigen, the merger of the antibody and the antigen. These connections have become visible under the fluorescent dye as a result of the dyeThe microscope and the patient is positive for this particular disease. Laboratory specialists usually use this extensive testing process to detect human immunodeficiency virus (HIV), Lyme disease and certain types of encephalitis. The conjugated antibodies marked with radioactive particles act as guidance equipment, allowing doctors to determine the location of the tumor and possible cancer metastases. These labeled antibodies generally circulate the body until contact with tumors. Cameras designed to monitor these particles illuminate the affected areas.

Using special chemical linkers, scientists load antibodies with cytotoxic drugs targeted therapy. Circulation conjugated antibodies locate abnormal tissues, which triggers the release of chemotherapeutic drugs. While targeting affected tissue, this type of therapy minimizes damage to healthy surrounding tissues. Oncologists sometimes use this method of treatment for non-HOdkkin's lymphoma when other therapies fail.

The company that produces conjugated antibodies usually uses monoclonal or polyclonal antibodies to produce them. Monoclonal antibodies are cloned from a unique cell line. Scientists combine animal cells with the desired antigen, which then produces a specific antibody. The production of polyclonal antibodies involves injection of an animal with a specific antigen. After some time, the animal produces antibodies in response that laboratory technicians acquire blood samples.