What are amyloid plaques?

amyloid plaques consist of aluminum silicates and amyloid peptides in nerve tissue. The sticky plaque accumulates around the nerve cells in the brain and disrupts normal brain activity. Amyloid plaques are associated with several diseases, including Creutzfeldt-Job's disease, but are most often associated with Alzheimer's disease. Together with neurofibrillary tangles, amyloid plaques are considered to be the main contributing to the symptoms of Alzheimer's disease.

This type of plague is one of the two brain abnormalities most commonly associated with Alzheimer's disease. To confirm the diagnosis of Alzheimer's disease, it is usually necessary to presence of amyloid plaques and neurofibrillary tangled. In fact, the presence of amyloid plaque often prevents symptoms of behavioral patients with Alzheimer's disease.

amyloid plaques are located on external neurons, while neurofibrillary tangles are located on them. Both can indeed be found in the brains who do not have Alzheimer's CHOrobu. The problem is not their presence, but rather a mere number that creates problems.

Amyloid is a protein. It is normally found throughout the body. People with Alzheimer's disease are incorrectly divided by amyloid protein. It creates a form that is referred to as beta amyloid. This beta amyloid is toxic to the neurons that are in the brain.

beta amyloids also form small holes in neural membranes. This causes the input of calcium. Too much calcium kills neurons. Due to these degenerational neurons, plaque begins. The body cannot break the plaque properly, so it starts to build in the brain.

Gene Apoe4, often referred to as the "Alzheimer gene", is a genetic abnormality that was firmly associated with the risk of developing Alzheimer's disease. Scientists now think it can be involved in the formation of amyloid plaques. It is assumed that the Apoe4 gene produces a protein that captures the beta amyloid.

molecules called free radicals play a role in damage that also leads to Alzheimer's disease. Some studies suggest that damage caused by oxidation and inflammation comes not only from the accumulation of amyloid plaques, but may actually be preceded by damage caused by free radicals. Although scientists know that the amyloid beta proteins that form plaque are able to produce free radicals and cause other healthy cells to do so, some studies now indicate that free radicals can cause damage before plaque.