What Is Ebola?

Ebola virus is also translated as Ebola virus. Is a very rare virus, found in southern Sudan and the Democratic Republic of the Congo (formerly known as Zaire) in 1976, its existence, caused widespread concern and attention in the medical community, "Ebola" Hence the name. Is a generic term used to refer to a group of viruses belonging to the family Fibrovirus Ebola virus.

Ebola virus is highly dangerous

Research by British scientists has shown that you should not eat foods that contain protein, but in Côte d'Ivoire, there is a way to boil cow urine and drink it.

The only way to fight it today is to inject an NPC1 inhibitor. Ebola virus needs to enter the nucleus through NPC1 to replicate itself. The NPC1 protein transports cholesterol between cells, even if the inhibitor will block the cholesterol transport route.

2014 :

Because of the extremely high lethality of Ebola virus,

Outbreak in Zaire in January 1995 and in Gabon since February 1996: 316 cases occurred in Kikwit, 245 cases died, 78% fatality rate; in Ogowei, Gabon Ogooue Ivindo had 46 cases of morbidity and 31 deaths with a mortality rate of 67.4%. According to the latest figures released by the World Health Organization, 1,100 people worldwide have been infected with the virus, and 793 of them have lost their lives. The medical community has yet to find a vaccine to prevent Ebola, its source, and no effective treatment. ^[5]

Laboratory infections: Ebola laboratory infections have been reported at least twice, once in 1976, at the Porton Down Institute of Microbiology (RME) in the United Kingdom. A staff member transferred Ebola-infected guinea pig liver homogenates in the laboratory. The needle penetrated the thumb and became infected. Another was in May 2004 in Victor Laboratory, Russia. A female scientist accidentally punctured her finger with a syringe needle infected with the virus and died of the infection.

From June to November 1976. In southern Sudan, a total of 284 cases occurred and 151 died, with a fatality rate of 53%. From September to October 1976 in the DRC (formerly known as

As of August 2014, China has 5 BSL-3 (commonly known as P3) laboratories that can detect Ebola virus, and conduct laboratory diagnosis of Ebola virus infection in on-look or suspected cases. ^[68]

In 1994, American writer Preston wrote the novel

On October 3, 2014, the prevailing opinion was that Ebola was transmitted by contact; however, several medical experts recently said that Ebola virus may mutate to spread through breathing. Two more experts believe that the current form of Ebola virus has been transmitted through aerosols. If this is the case, if Ebola cannot be quickly controlled, it may spread to the whole world.

Currently, the prevailing perception is that Ebola virus is transmitted mainly through contact, not through air; only patients who have Ebola symptoms are contagious.

The New York Times reported that Michael T. Osterholm, director of the University of Minnesota's Center for Infectious Diseases, said that the Ebola virus is notorious for its replication, and the virus that enters human A may be genetically different from human B. The current rate of Ebola virus transmission is unprecedented. The amount of human-to-human transmission in the past four months is likely to exceed the total of the past 500-1000 years.

Osterholm said that if certain viruses mutate, they may progress to respiratory transmission. If that were the case, the Ebola virus would spread quickly worldwide. Government officials dare not talk about this because they don't want to be accused of being the one shouting fire in a crowded theater. Osterholm believes that this need to be pointed out, and people need to be prepared.

In 2012, several Canadian researchers confirmed that the Zaire Ebola Zaire virus can be transmitted from pigs to monkeys through the respiratory tract, and that the lungs of these two animals are similar to humans. The Zaire Ebola virus is a virus that is spreading in West Africa. Richard Preston's book "The hot zone" documents the 1989 outbreak of Reston's Ebola virus, which spread among monkeys through breathing. All monkeys were euthanized before the epidemic came to an end.

According to Guardian, the chairman of the United Nations Ebola emergency team said that if the current epidemic could not be controlled quickly and effectively, there could be such a horror-the Ebola virus has developed into airborne transmission.

Two national-level infectious disease experts at UIC University believe that the current form of Ebola virus can already be transmitted through aerosols. There is scientific and epidemiological evidence that Ebola virus may be transmitted through aerosol particles, suggesting that medical workers should wear respiratory masks rather than masks.

Aerosol, also called aerosol, aerosol, refers to a dispersion system in which solid or liquid particles are stably suspended in a gaseous medium. The general size is between 0.01 and 10 microns, which can be divided into two types: natural and human. ^[74]

The first confirmed Ebola carrier in the United States, 42-year-old Thomas Eric Duncan, died in the isolation ward of the Texas Hospital on the morning of the 8th. "We announce with great sadness and extreme sorrow that Duncan died at 7.51 this morning. Mr. Duncan died of an illness," said Wendell Watson, a spokesman for the Dallas State Health Presbyterian Hospital in Duncan. Ebola, who has fought bravely against the disease. Our professionals, doctors and nurses, as well as the Texas Health Presbyterian Hospital in all Dallas communities, are deeply saddened by his death. "

The Liberian Duncan, who arrived in Texas in mid-September to visit relatives, was the first patient in the United States to be diagnosed with Ebola and became the first person to die from the disease in the United States.

Duncan had been exposed to the deadly Ebola virus before leaving Liberia, and he did not show any symptoms when he arrived in the United States on September 20. A few days later, Duncan felt unwell and went to the emergency room of the Presbyterian Hospital. The hospital ignored his travel records and sent him home. Two days later, Duncan was returned to the hospital by ambulance for "strict isolation." On September 30, the US Centers for Disease Control and Prevention confirmed that Duncan was the first patient with Ebola virus found in the United States.

The negligence of the hospital exposed more people to the danger of infection. The 48 family members, health care workers and friends who have had direct or indirect contact with Duncan are currently under quarantine or closely monitored. ^[75]

The Italian National Institute of Infectious Diseases recently issued a statement saying that it has developed a portable device for rapid detection of Ebola virus, which can detect the presence of Ebola virus in blood samples in 75 minutes.

This equipment was developed by the institute in cooperation with Italian biotechnology company Clonit and French company STMicroelectronics Co., Ltd., using molecular biology technology for real-time polymerase chain reaction. This kind of equipment has extremely high sensitivity. Even a trace amount of human blood can be diluted to detect the virus contained in it, and it can identify the virus at an early stage and significantly reduce the risk of infection. ^[76]

Ebola virus ostrich egg antibody

On November 23, 2014, Kyoto Prefectural University of Japan announced that its research team has developed a technology for mass production of antibodies against Ebola virus using ostrich eggs, and some airports plan to use sprays containing this antibody in mid-December.

The ostrich has strong immunity, which is due to its strong antibody-producing ability. Professor Kyoto Hiroshi Tsukamoto and his team have been studying the immunity of ostriches, and have developed a technology that uses ostrich eggs to extract antibodies in large quantities.

In the new study, the research team first developed a recombinant protein of Ebola virus and injected it into the ostrich as an antigen. The ostrich generates antibodies and passes them to the eggs it produces. After removing the yolk portion of the ostrich eggs, the antibodies can be purified. The research team currently plans to use the antibody to make an infection-preventing spray that can be sprayed on hands, masks, and door knobs. ^[77]

Ebola virus nucleic acid detection reagent

On April 27, 2015, the WHO officially announced the approval of the Ebola virus nucleic acid detection kit developed and manufactured by Zhijiang for inclusion in its official procurement list. At the same time, this product was used as one of the detection methods for Ebola virus. Recommended worldwide.

In just one year, Made in Shanghai Ebola testing products have gained international popularity. The seemingly easy harvest, but it is the "inadvertently inserting willows" for 5 years.

In 2010, by chance, an African customer asked Zhijiang to develop an Ebola test reagent. Faced with the "money-losing orders" that businessmen can count on, Shao Junbin thought about innovation and service: "There are few orders and a small market, and it does not make money. However, since the company promises to provide value-added services to customers, we should invest R & D. "Thanks to the bioinformatics team that was set up at the beginning of the company's establishment, the company began to develop Ebola detection kits since 2010, and successfully developed within 5 months.

The kit obtained EU CE certification in February 2014, becoming the first Ebola virus nucleic acid detection product in the world to obtain EU CE certification. After the Ebola outbreak in Africa, the product was first used in national reference laboratories such as Sierra Leone, Liberia, Nigeria, etc., and the effect was good. At present, reagents are mainly sold to Nigeria, Guinea, Cameroon, Kenya, the United States, India and other countries; there are 35 domestic procurement units for reserves as reagents. The enterprise can produce 50,000 reagents in 3 days. ^[78]