What Is Lupus Vasculitis?

Lupus vasculitis (SysteniC / upuSerythemato_uS, SLE) is an autoimmune connective tissue disease involving multiple organs such as skin, joints, serosa, kidney, cardiovascular, and central nervous system.

Lupus vasculitis

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Lupus vasculitis (SysteniC / upuSerythemato_uS, SLE) is the skin, joints, serosa, kidney, heart

National Peripheral Vascular Disease Treatment Center

Regarding the etiology of lupus vasculitis, Chinese and Western medicine have different understandings:

(1) Chinese medicine believes

The disease is mostly congenital deficiency, liver and kidney yin deficiency, insufficiency of essence and blood, plus acquired pathogenic factors such as internal emotional injuries, overwork,

Six sexual infestation attacks, sun exposure, causing poisonous heat and internal prosperity, obstructing the veins, internal invasion of viscera, joints, bones and bones, and external skin damage. This is the standard of deficiency, the deficiency of heart, spleen and kidney, and blood deficiency. The symptoms of depression, heat, fire, stagnation, and accumulation of drink are the standard.

(B) Western medicine believes

The cause is unknown. At present, it is believed that it is related to the combined effects of genetics, endocrine abnormalities, and environmental factors on the body's immune dysfunction. Due to impaired immunoregulatory function, various lymphocyte subpopulations are reduced, suppressor T cell function is abnormal, IL-2 production is reduced and response is reduced, B cell activity is abnormally increased, a variety of autoantibodies are generated, and they are combined with corresponding antigens to form Antigen-antibody immune complexes are deposited on joints, small blood vessels, glomeruli, etc., and are caused by complement reactions.

1. Onset can be acute, subacute, or chronic. Involved organs have occurred one after another, with different severity, different clinical manifestations, and those with atypical initial clinical manifestations are often misdiagnosed. At the time of the onset, there is usually general fatigue, weight loss, fever, arthritis or joint pain (about 90%). About half of the patients have myalgia, muscle atrophy, muscle weakness, skin erythema, oral mucosal ulcers, lymphadenopathy, and dirty Organ involvement, often one or two organ involvement, and gradually develop to multiple organs;

2. 50% -80% of patients develop lupus nephritis, manifested as nephritis or nephrotic syndrome;

3. The nervous system is more commonly affected by the central nervous system, showing neurological and mental symptoms;

4. Respiratory system involvement manifests pleurisy and interstitial pneumonia;

5. The digestive system is affected by loss of appetite, nausea and vomiting, abdominal pain and diarrhea, and hepatosplenomegaly.

1. The disease is a relatively common autoimmune disease that recurs and affects multiple organ systems. Vasculitis is both its pathological basis and its typical clinical manifestations. Various clinical manifestations can occur, such as Raynaud Shigren's sign, frostbite-like rash, skin nodules or ulcers, finger / toe gangrene, etc., even visceral damage can occur, such as pulmonary vasculitis can cause pulmonary interstitial disease, pulmonary fibrosis, etc .; cerebral vasculitis can cause lupus encephalopathy , Cerebral embolism or cerebral hemorrhage; renal vasculitis can cause proteinuria, hematuria and so on. Modern medicine believes that mainly immune complexes and various cellular inflammatory factors such as tumor necrosis factor (TNF), interleukin (IL), etc., activate vascular endothelial cells to cause damage to the vascular wall, cause vascular embolism, and cause vascular and tissue necrosis. In the theory of traditional Chinese medicine, it is believed that these clinical manifestations are caused by heat and poison, and qi stagnation and blood stasis. Due to the hot heat in the human body, the qi and blood can not run smoothly, and blood stasis is formed. Therefore, the skin is swollen and bruised, and the symptoms worsen when it is cold, and gangrene appears in the fingers and toes in severe cases. Heat poisoning can also damage the internal organs. If the lungs are invaded, cough, sputum, hemoptysis, and even chest tightness, shortness of breath, and dyspnea may occur. If the brain is invaded, headaches, head swelling, nausea, vomiting, and even unconsciousness may occur. Qing, slang, coma and other symptoms; if the invasion of the kidney can appear edema, oliguria, hematuria and other symptoms.

2. From a long-term perspective, the overall regulation and dialectical treatment of traditional Chinese medicine treatment has more root causes than symptomatic treatments. It enhances the curative effect and reduces hormone side effects, prevents infection, reduces and withdraws hormones, stabilizes the disease, prevents recurrence, maintains long-term relief, corrects vulnerable constitutions, and achieves overall. Rehabilitation has many advantages. A large number of clinical practice and experimental studies have proved that the combined effect of combining traditional Chinese and western medicine to enhance strengths and avoid weaknesses is obviously better than pure western medicine or pure Chinese medicine. Is currently the best treatment for lupus patients.