What Are Psoralens?
Experimental results show that the drug has a strong killing effect on leukemia cells (IC50 is 4ug / ml), that is, leukemia cells are more sensitive to psoralen. The killing effect of the drug has no significant difference between acute lymphocytic leukemia cells and acute myeloid leukemia cells. When the concentration of psoralen is between 8 and 2 ug / ml, the killing effect on leukemia cells decreases significantly.
Psoralen
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- experiment
- [Chinese name]
- Psoralen is a photosensitive compound that needs to be supplemented with sunlight or ultraviolet radiation. After the treatment, the damaged melanocytes adjacent to the damaged cells are not completely destroyed or normal, which increases the tyrosinase activity and promotes melanin synthesis.
- Psoralen
- 7H-Furo (3, 2-g) (1) benzopyran-7-one
- 186.16
- China Research Center for Traditional Chinese Medicine states that psoralen and its derivatives are all photosensitising
- Colorless needle-like crystals (ethanol). 160-162 ° C. Soluble in ethanol, chloroform, slightly soluble in water, ether and petroleum ether.
- Measurement of psoralen by radioimmunoassay
- (I), 8-methoxy psoralen
- () Changes in the level of cyclic nucleotides in S180 cells after interaction with mouse S180 cells. The experimental results show that: and can significantly increase the level of cyclic nucleotides in S180 cells and the level of cAMP in S180 cells. It has no significant effect on its cGMP level, thereby significantly increasing the ratio of cAMP and cGMP, which can inhibit excessive cell proliferation. For every million EAC cells, psoralen is 0.0025ug, which can be completely killed under 3.655A light irradiation; it can be combined with leukemia L1210 cells, and combined with cyclophosphamide can significantly reduce animal mortality.
- LD50 (mg / kg): mice were given 615 orally and 480 subcutaneously; rats were given 1330 orally and 8l0 subcutaneously.
- Legume Psoralea corylifolia L. Fruit, Umbelliferous Plant Glehnia littoralis Fr. Schmidr ex Miq, Rhizome, Herpidium Heracleum lanatum Michx. Leaf, Ruta Plant Ruta (Begonia) Ruta graveolens L. Whole Grass, mulberry fig Ficus carica L. leaves and roots.