What are the possibilities of using cimetidine for cancer?
cimetidine is a commonly used over -the -counter medicine that treats heartburn and other stomach disorders, which are also sold under the Tagamet® brand. Possible use of cimetidine for cancer was discovered in the 70s, when several patients with cancer have improved spontaneously, taking cimetidin for burning and several decades of research of mechanisms behind this phenomenon. Some studies have brought that cimetidine seems to cause some improvement in many cancer patients and can help slow the spread of cancer, especially in certain stomach cancer and in combination with further treatment. However, the results of these studies suggest that more research has been needed since 2011. The advantages of cimetidin for cancer victims were first postulated in 1979, for two years after cimetidin was first approved by the US Food and Drug Administration and three years after it first appeared in the UK. Scientists first became interested in exploring the use of cimetidine for cancer after cancer patientsThey used a drug for stomach problems, their conditions have been improved. This created a study of lung cancer, indicating that cimetidine seemed to have anti -tumor activity. Over the next two decades, many studies were followed by mice and human subjects.
In 2002, a Japanese study followed two groups of patients with colon cancer. One group received a 5-fluorouracil and cimetidine, while the other group received only 5-fluorouracil for almost a year. The ten -year survival rate of the cimetidine group approached 85 percent, while the non -cimetidine group was around 50 percent. Scientists have noticed that Cimeplidine's greatest efficacy for cancer was against cells that have expressed the largest amounts of Sialyl Lewis antigens that control cell recognition to cells and help attract certain types of cells to each other.
The United Kingdom's study tried to determine mEchanism for perceived effectiveness of cimetidine for cancer. Scientists assumed that the drug had improved immune systems of cancer patients while preventing cancer cells to stick to the epithelium. The results supported this hypothesis. Simply put, cimetidine seems to help prevent the spread and metastasis of cancer to other areas of the body.
Colorectal tumors contain high amounts of histamine, which is assumed to stimulate tumor growth. Cimetidine may have a change in the way histamine affects tumors and inhibits tumor growth. However, there are other drugs that act in the same way against histamine as cimetidine, which lack its efficiency, so the exact path for its efficiency may not be found. In these studies, further research has supported initial findings and new research has shown that cimetidine is effective against other types of cancer.
as cancer treatment has not been approved by US food and drug administration since 2011, but often afterIt is consuming a safe, affordable alternative treatment that can be used in conjunction with traditional chemotherapy and surgery. The side effects are mild and usually well tolerated. Although the drug is not recommended for long -term use, some doctors claim to be safe to use for cancer treatment. As with any drug, cimetidin should not be taken for purposes other than the intended use, except for the advice of a qualified doctor.