What factors affect a sufficient dose of tranexamic acid?
Transexamic acid is a drug that helps the blood clotting process by reducing the activation of plasmin, an enzyme that degrades natural clotting such as fibrin. There are many factors that affect the dose of tranxamic acid used in medicine, including the clinical reason that the drug is used. Other factors include the patient's kidney function, body weight and the way the drug is administered. This dose can be used up to three times a day, a total of 3,900 mg per day. For this purpose, these doses are only used for five days each month. Using in a surgical environment, injection is often used instead of oral tablets and the dose of tranexamic acid used is 1 10 mg for each kilogram (kg) that the patient weighs. This dose may usually be administered 2 to 4 times a day for up to 8 days after the operation.
both adults and children generally receive similar doses of this drug if used to reduce bleeding during operationsE heart disease. The dose of tranexamic acid for this purpose is somewhat larger than the dose for tooth extraction. Initially, the dose is 100 mg per kg body weight, followed by 10 mg per kg every hour, with another 100 mg per kg at the beginning of the bypass.
scoliosis surgery is another situation where this medicine can prove useful. This surgery uses a dose of variable load and subsequent dose depending on the opinion of the physician and the severity of the surgery. In this case, the initial dose of tranexamic acid can range from 10 mg/kg to 100 mg/kg, followed by an hourly infusion of 1 mg/kg up to 10 mg/kg to the skis.
In patients with kidney damage, tranxamic acid dose must often be reduced. Individuals with creatinine levels above 5.7 mg per decatalite (DL) of blood should take half of the usual recommended dosage of this drug. For menstrual bleeding it would be 650 mg orally, three times a day. In a surgical environment, a dose of drug during tooth extraction would be reducedILA at 5 mg/kg. However, liver damage does not affect the dose.