What Is Manidipine?

Manidipine, an antihypertensive drug. The free base is pale yellow crystals. Insoluble in water, soluble in ether, mp125 ~ 128 . There are heterogeneous crystals, -type is yellow crystals, insoluble in ethanol, acetone and ether, and soluble in water. mp157 ~ 163 ; -type is light yellow fine crystal, insoluble in ethanol, ether and acetone, soluble in water. mp174 ~ 180 .

Drug Name: Manidipine
Foreign name: Manidipine

Main indications: hypertension
Drug type: Antihypertensive drugs

Basic information

Chinese name: Manipipine

Chinese alias: (-)-2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid 2- (4-diphenylmethyl- 1-piperazinyl) -ethyl methyl ester; malidipine

English name: Manidipine

English alias: (4S) -1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2- [4- (Diphenylmethyl) -1-piperazinyl] ethyl Methyl Ester; METHYL 2- (4-BENZHYDRYLPIPERAZIN-1-YL) ETHYL 2,6-DIMETHYL-4- (3-NITROPHENYL) -1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE; 2- (4- (diphenylmethyl) -1- piperazinyl) -ethyl methyl (-)-2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate;

CAS number: 120092-68-4

Molecular formula: C ₃₅ H ₃₈ N ₄ O ₆

Molecular weight: 610.69900

Exact mass: 610.27900

PSA: 116.93000

LogP: 5.68080

Physical and chemical properties

Density: 1.232g / cm ³

Melting point: 125-128ºC

Boiling point: 722ºC at 760 mmHg

Flash point: 390.4ºC

Refractive index: 1.6

Storage conditions: -20ºC

Vapor pressure: 1.07E-20mmHg at 25 ° C ^[1]

Structural formula:

Manifedipine related drug label information

Pharmacological effects of Manidipine

This product is a dihydropyridine calcium antagonist. Spontaneously hypertensive rats, two kidney-clamp type hypertensive rats, deoxycorticosterone acetate hypertensive rats and renal hypertensive dogs all have a dose-dependent hypotensive effect. Its effect is stronger than that of nicardipine and nifedipine and it lasts longer. This product is selective for resistance vessels and can expand. Renal blood vessels have less inhibitory effects on the myocardium and conduction, and have no adverse effects on blood lipids.

medicine interactions

This product may enhance the effects of hydroxy digitalis and cimetidine.

Pharmacokinetics

This product is rapidly absorbed orally, the peak time is 1 to 2 hours, and the area under the curve of peak concentration and drug time increases with dose. Its s () isomer is twice as effective as R (-). Elimination of half-life 5h. The plasma protein binding rate reached 97%.

Dosage form and specifications

Tablet: 5mg / tablet.

Manidipine indication

It is used for hypertension, especially for patients with low renin type hypertension. It is also suitable for those with impaired renal function.

Manidipine notes

Banned for pregnant and lactating women. Cardiogenic shock is disabled. Severe liver function should be used with caution. Use with caution when working at height and driving. The elderly should start taking low doses.

Manidipine adverse reactions

The incidence of adverse reactions was 10.4%. Mainly rash, itching, flushing, hot flashes, palpitations, dizziness, headache, heavy head, numbness, nausea, vomiting, stomach upset, bloating, constipation, thirst, burnout, fatigue, edema, frequent urination, etc. Occasionally, AST, ALT, alkaline phosphatase, urea nitrogen, and creatinine increased, white blood cells decreased, and total cholesterol, uric acid, and triacylglycerol increased.

Manidipine dosage

Oral, 5mg each time, once a day, can gradually increase to 10-20mg, once a day ^[2] .

Manidipine uses

Calcium antagonist. It has a strong role in relaxing arterial smooth muscle, dilating blood vessels, reducing peripheral vascular resistance and arterial pressure. It is used for the treatment of essential hypertension, which has a more obvious antihypertensive effect on low renin type hypertension and can improve uric acid metabolism.