What is the relationship between sertraline and dopamine?
The relationship between sertraline and dopamine lies in the unique effect that has a selective inhibitor reuing serotonin (SSRI) on the dopamine track. Sryrtralin has the ability to partially block dopamine back pumps. When the dopamine pumps are blocked, it is left more dopamine to circulate in synaptic split, leading to increased neurotransmisia and effect. Sryrtralin and dopamine are often considered to be together in psychiatry, because sertraline is the only known SSRI that has a significant impact on the dopamine path. It is believed that this additional ability to interact with dopamine is responsible for the effectiveness of the drug and a unique effect on depression and other mental diseases. While serotonin receptors, target neurotransmitter for most antidepressant drugs, it is found that the brain is abundant, most dopamine receptors are located in specific areas near the brain stem. One of the areas where receptors are found is the mesolimbic path that is known to beSignificantly important for experience with pleasure, joy and reward, as well as for adequate motivation to complete everyday life. It is assumed that dopamine actions caused by sertraline in this area contribute to its positive effect on depression, anxiety and many related disorders. The specificity of brain and active dopamine areas has led to the new class of antidepressant drugs to study the affinity of sertraline and dopamine.
The paths of sertraline and the dopamine of the cross in the area called the Igrostriatal road also. Here, increased dopamine in synaptic cleft can help the patient more effectively plan, reduce anxiety and increase dopamin activity increases knowledge, which may lead to a higher sense of fulfillment and interest in life activity. The interaction of sertraline and dopamine is also observed in thalamus, in an area that is important for the transfer of information throughout the body. In light tThe research for doctors has become easier to understand the role played by dysregulation in mental illness, such as schizophrenia and attention disorder, diseases in which smooth transmission of information is inhibited.
Anhedonia, a serious symptom of depression, which is characterized by the absolute inability to feel pleasure, in some cases can be alleviated with drugs that increase dopamine. Well explored binding between sertraline and dopamine has led to success in using SSRIs for use outside the brand, such as the treatment of generalized anxiety disorders (GAD). The combination of sertraline and dopamine led to many clinical doctors in the field to recognize the likelihood that serotonin is not exclusively responsible for diseases such as the main depressive and bipolar disorder.