What is antineutrophilic cytoplasmic antibody?
Antineutrophilic cytoplasmic antibody (ANCA) is a protein produced by the body's immune system and is associated with a number of different diseases. Protein is considered to be autoantilate because it suggests that the immune system of the body attacks alone. Whether a person has an anca blood is determined by a commonly performed diagnostic test that is indicated when patients have certain symptoms. Two different types of ANCA, C-ANCA and P-ANAs are associated with diseases such as Wegener's granulomatosis, microscopic polyarteritis, Churg-Strauss syndrome and polyarteritis nodosa. For example, if a person is exposed to a virus, his body could begin to produce antibodies that bind to this pathogen and help facilitate its elimination from the body. Sometimes the immune system of dysfunction and begins to produce anti -folders of their own body components, and these are referred to as autoantibodies. Antineutrophilic cytoplasmic antibody is one of these autoantibodies because it represents a body attacking its own neutrophils, which are whiteEr blood cells that are important parts of the body's defense.
whether the person produces antineutrophilic cytoplasmic antibody can be evaluated by checking the blood sample. Antibodies are often divided into two classes, central ANCA (C-Adena) and peripheral anca (P-Adena). The distinction between these two classes depends on the laboratory study that locates which part of the neutrophil the antibody attacks. Patients who have C-Adena have antibodies attacking the central areas of neutrophils, usually because antibodies attack a substance called proteinase-3. Those with P-anca have antibodies focused on myeloperoxidase, which a deer located in the external areas of these neutrophils.
A number of different diseases are associated with antineutrophilic cytoplasmic antibody. The presence of c-anca is most closely associated with the condition called Wegener's granulomatosis, a disease in which the body attacks on the middle blood vessels throughout the bodiese. Symptoms associated with this disease may change, but may include cough, kidney failure, lung disease, muscle pain, fever and weight loss.
Positive peripheral antineutrophilic cytoplasmic antibodies are associated with several different autoimmune diseases. It is strongly connected with conditions called polyarteritis Nodosa, Churg-Strauss syndrome and microscopic polyarteritis. These three diseases are all forms of vasculitis, a general term for the condition associated with inflammation of the blood vessels of the body.