What is the heavy string of immunoglobulin?

The

immunoglobulin heavy string is one of the four main components of the antibody and is composed of 450 to 550 amino acids. All immunoglobulin is produced by plasma cells when an immune response is initiated in the body. The name Imunoglobulin comes from the discovery that they bind with globular proteins in series that contain an antibody. The term "heavy string" concerns the length of the polypeptide sequence, which can be compared with a light chain of immunoglobulin, which has only about 200 amino acids. The binding of antigen is the most important function of the heavy string of immunoglobulin, but in some cases this initial binding does not provide immune protection or other function until another "effector reaction" such as immune reactions in itself may be bound to immune immune reactions. For example, lymphocytes, the main "fighter" cells of the body, phagocytes that are cells that absorb and destroy foreign substancesY, and the plates in the blood, have the receptor for immunoglobulin. Another function of the heavy immunoglobulin chain is to help to tie immunoglobulin to receptors on cells called trophoblasts found on the placenta during pregnancy. This binding allows immunoglobulin to transmit through the placental barrier, resulting in transferred antibodies and inherited immunity from the mother to the newborn. Fixation of other chemical supplements with immunoglobulin is responsible for activities such as lies of undesirable cells and initiated release of secondary chemicals.

specific parts of the heavy string of immunoglobulin, which contain most of the binding areas of antigen, are called FAB fragments. Immunoglobulin is often divided into its basic pieces than FAB fragments can be used effectively. Enzyme, papain, breaks immunoglobulin in its suspended areas that produces two identical heavy strings of immunoglobulin and two identical immunoglObulin light chains. Fab FC Fragment is one of the FAB fragments, which is only on the heavy immunoglobulin chain. The FAB FC Fragment contains two areas, specifically known as H2 and H3, and any immune -mediated activity that uses these sections depends on the disintegration of immunoglobulin molecules because it leaves H2 and H3 exposed on heavy chains.

Immunoglobulin is often organized by scientists into five classes based on easily apparent differences in the amino acid sequence on their heavy chain. The differences can be detected by directing antibodies on heavy immunoglobulin chains and recording their biological reaction or deficiency. Some common class immunoglobulin classes include the heavy chain of gamma (IgG), Murse Chain (IgM) and Alpha Heavy Chain (IgA).