What Is an Actin Antibody?

.Actin is a kind of spherical multifunctional protein that forms microfilaments. It is found in almost all eukaryotic cells, where it can be present at a concentration of more than 100 M; its mass is about 42 kDa and its diameter is 4 to 7 nm.

Actin is a type of muscle structural protein. Plays an important role in muscle movement. It is present in the filaments of striated muscle fibrils and also in smooth muscle. It is also an important motor protein in cells ^[1]

Actin is a globular protein with a molecular weight of about 42,000 to 48,000 and a molecular diameter of about 5 nanometers. An actin molecule binds an adenosine triphosphate molecule. Spherical actin can associate with fibrous actin. The latter two strands are twisted together to form a skeleton, which is then embedded with tropomyosin and troponin to form the filaments of myofibrils in the muscle ^[1]

Its amino acid sequence is also the most highly

The main interactions of structural proteins are based on

Actin filaments ('F-actin' or

There are many toxins that can interfere with the dynamics of actin by preventing actin polymerization (latrunculin and cytochalasin D) or by stabilizing it (phalloidin):

• Latrunculin is a toxin produced by a sponge that binds to G-actin, preventing it from binding to microfilaments.

• Cytochrome D is an alkaloid produced by fungi that binds to the (+) end of F-actin, preventing the addition of new monomers. Cytocalasin D has been found to disrupt actin dynamics and activate protein p53 in animals.

• Phalloidin is a toxin isolated from the dead mushroom Amanita phalloides . It binds to the interface between adjacent actin monomers in the F-actin polymer, preventing its disaggregation.