What Are Thyroid Peroxidase Antibodies?

Anti-thyroid peroxidase antibody refers to thyroid tissue autoantibodies and is closely related to thyroid tissue immune damage.

Antithyroid peroxidase antibody

Anti-thyroid peroxidase antibody refers to thyroid tissue autoantibodies, and thyroid tissue

TPOA direct confrontation

In patients with primary hypothyroidism, combined with elevated TSH, early hypothyroidism can be detected. For patients with suspected hypothyroidism, if TPOA is elevated, it helps to distinguish between primary and secondary hypothyroidism. In HT patients, TPOA survives for a long time. If the clinical manifestations are typical and the TPOA level is persistently high, it can be used as a diagnosis basis for diagnosis.

For indications of thyroid hormone replacement therapy, including patients with elevated TSH levels and anti-thyroid peroxidase TPOA-positive patients, clinical combined testing of TPOA and TGA is mainly used to identify the effects of immunotherapy and to identify people with familial thyroid disease. Possibility of disease and prediction of postpartum thyroid dysfunction in pregnant women.

Detection of TPOA helps to solve clinical diagnosis problems, such as abnormally high TSH levels accompanied by normal levels of free T4 (FT4). If TPOA is elevated, subclinical hypothyroidism and early chronic lymphocytic thyroiditis should be considered. Low levels of TPOA account for 10% of asymptomatic patients, indicating a susceptibility to thyroid autoimmune diseases; 85% of patients with hyperthyroidism and hypothyroidism show high levels of TPOA. Therefore, in the diagnosis of most thyroid autoimmune diseases, TPOA and TGA combined detection has higher clinical value.

In addition, TPOA may be positive in patients with postpartum thyroiditis, atrophic thyroid, and partial nodular goiter; some autoimmune diseases such as rheumatoid disease and systemic lupus erythematosus can increase TPOA.