What Is Achlorhydria?

Stomach acid deficiency, bacteria easily reproduce in the stomach, can cause chronic gastritis. Chronic gastritis refers to a variety of chronic gastric mucosal inflammatory lesions caused by different causes. It is a common disease and one of the most frequent diseases in the army. Its incidence rate ranks first among various gastric diseases. Since the widespread application of fiber endoscopy, the understanding of this disease has improved significantly. Chronic gastritis often has a certain degree of atrophy (loss of mucosa) and metaplasia, often involving the cardia, accompanied by loss of G cells and reduced gastrin secretion. It can also affect the body of the stomach, accompanied by the loss of acid secreting glands, leading to gastric acid. Reduction of pepsin and endogenous factors.

Gastric acid deficiency

Stomach acid deficiency, bacteria easily reproduce in the stomach, can cause chronic gastritis. Chronic gastritis refers to a variety of chronic gastric mucosal inflammatory lesions caused by different causes. It is a common disease and one of the most frequent diseases in the army. Its incidence rate ranks first among various gastric diseases. Since the widespread application of fiber endoscopy, the understanding of this disease has improved significantly. Chronic gastritis often has a certain degree of atrophy (loss of mucosa) and metaplasia, often involving the cardia, accompanied by loss of G cells and reduced gastrin secretion. It can also affect the body of the stomach, accompanied by the loss of acid secreting glands, leading to gastric acid. Reduction of pepsin and endogenous factors.

Causes of gastric acid deficiency

First, after the acute gastritis acute gastritis, the gastric mucosal lesions are persistent or recurrent, can form chronic gastritis.

2. Stimulant foods and drugs Long-term use of diets and drugs that have a strong irritation to the gastric mucosa, such as strong tea, spirits, spicy or salicylates, or inadequate chewing when eating, rough food repeatedly damage the gastric mucosa, Or excessive smoking, nicotinic acid directly caused by gastric mucosa.

Third, duodenal fluid reflux studies found that chronic gastritis patients due to pyloric sphincter dysfunction often cause bile reflux, which may be an important pathogenic factor. Phospholipids in pancreatic juice, together with bile and pancreatic digestive enzymes, can dissolve mucus and destroy the gastric mucosal barrier, and promote the diffusion of H + and pepsin into the mucosa, further causing damage. The resulting chronic gastritis is mainly in the antrum. Gastric inflammation due to bile reflux is very common in patients with gastrojejunostomy. Almost all patients with peptic ulcer have chronic gastritis, which may be related to dysfunction of the pyloric sphincter. Chen Chunlian experts explained that nicotine in tobacco can relax the pyloric sphincter, so long-term smokers can promote bile reflux and cause gastritis.

4. Immune factors The changes in immune function have been generally valued in the onset of chronic gastritis. Atrophic gastritis, especially gastritis, can be found in the blood, gastric juice, or parietal cell antibodies in atrophic mucosa; patients with gastric atrophy and malignant anemia Internal factor antibodies were found in the blood, indicating that the autoimmune response may be the cause of some chronic gastritis. However, whether immune factors are involved in the onset of gastritis is inconclusive. In addition, the gastric mucosa of atrophic gastritis has diffuse lymphocyte infiltration, and the abnormality of the in vitro lymphoblast transformation test and leukocyte migration inhibition test indicates that the cellular immune response may have important significance in the occurrence of atrophic gastritis. Certain autoimmune diseases such as chronic thyroiditis, hypothyroidism or hyperthyroidism, insulin-dependent diabetes, chronic adrenal insufficiency, etc. can be accompanied by chronic gastritis, suggesting that this disease may be related to the immune response.

V. Infectious factors In 1983, Warren and Marshall found that patients with chronic gastritis had a large number of Campylobacter pylori near the epithelial cell surface of the gastric antrum mucus, and the positive rate was as high as 50-80%. It was reported that the bacteria was not normal. Gastric mucosa. Gastric mucositis cells infiltrated everywhere where the bacteria settled, and the degree of inflammation was positively correlated with the number of bacteria. Electron microscopy also showed that the number of microprojections on the surface of epithelial cells connected to bacteria was reduced or dulled. Anti- Helicobacter antibodies can also be found in patients' blood and gastric mucosa. After treatment with antibiotics, symptoms and histological changes can be improved or even disappeared, so it is believed that this bacterium may be involved in the pathogenesis of chronic gastritis. But it's hard to say for sure.