What Is Affinity Maturation?
Antibody affinity maturation refers to a state of immune function that is normally present in the body. In humoral immunity, the average affinity of the antibodies produced by the second response is higher than that of the first response. This phenomenon is called antibody affinity maturation.
Antibody affinity maturation
Right!
- Chinese name
- Antibody affinity maturation
- Foreign name
- antibody affinity maturation
- Nature
- An immune function state
- Meaning
- Body defense and maintenance of autoimmune surveillance
- Antibody affinity maturation refers to a state of immune function that is normally present in the body. In humoral immunity, the average affinity of the antibodies produced by the second response is higher than that of the first response. This phenomenon is called antibody affinity maturation.
- It is due to the genetic mutation of the antibody-forming cells themselves and the selective activation of B-cell clones by the antigen. This functional state of the body is the result of long-term evolution and continuous adaptation to the external environment, and is of great significance for the body's defense and maintenance of autoimmune monitoring.
- Definition: Only those B cells expressing high-affinity antigen receptors can effectively bind antigens and proliferate on antigen-specific Th cells to produce high-affinity antibodies. This is called antibody affinity maturation. Antibody affinity maturation is associated with high frequency mutations in somatic cells