What is affinity maturation?
Alfinity maturation is the reaction of the immune system. This term describes the type of lymphocytes called B-cells and how they respond to the exposure of the antigen. It is a process of variation and selection of cells.
The immune system is responsible for protecting the body from foreign antigens. This is done by creating antibodies that attack and neutralize antigens before they can cause problems. Affinity maturation is a process that dictates the role that B-cells have in the response of the immune system. Lymphocytes
B-cells are created in the bone marrow. When foreign antigen enters the body, B-cells are activated when they bind to antigen. After custody, the cells now have two tasks. The first task of maturing the affinity is to secrete antibodies that bind to specific antigens. Through this action, antigens are now marked for removal through a congenital system and its processes. And the B-Cell, who has completed the obligation process, must clone himself. Samoting often leads to new cells that have different pathogen receptors notThe mother cells. New cells can also bind to antigens, but only if new cells are highly attracted to antigens. These new cells continue to clone as parent cells.
When a B-cell, parent or cloned, has a high level of attraction to antigen, it is referred to as the affinity of the cell. B-cells with higher affinity to antigen are more likely to clone and have stronger affinity. All B-cells compete for binding with antigens available for binding. There will be some cells with stronger levels of affinities than others, so they will clone more than others.
Throughout the process, the affinity maturation is achieved when cloned cells create new cells. Cell cloning provides hyper-mutation so that every new generation of cells is attracted to antigen than the previous, which is a variation aspect. The selection aspect is evident in stronger cells that bind with antigens instead of weaker.
higher pathogen response in B-cells is important when the exposure to antigens is continuous or antigens continue to replication. B-cells and antigens have the ability to reproduce and create new, stronger cells. Like the affinity maturation of B-cells, antigen cells become stronger and more resistant to every new cell generation. It is a competition between two types of cells that determines which one is the strongest. In most cases, the immune system provides additional reactions to the invasion, giving B-cells another advantage.