What Is Lipoprotein Lipase Deficiency?

(1) Adipose tissue male: 1.10-4.00 mol FFA · h ^-1 · g tissue ^-1 (

LPL mainly includes extrahepatic lipase and HTGL, which are a kind of hydrolase in lysosomes, which act on the surface of vascular endothelial cells. They are similar in structure and belong to triglycerides, which are homologous to pancreatic lipase. Involved in fat metabolism in the body.

Name

Lipoprotein lipase

category

Biochemical tests

Lipoprotein lipase normal value

(1) Adipose tissue male: 1.10-4.00 mol FFA · h ^-1 · g tissue ^-1 (

: 2.46) 18.3-66.7U / kg (

: 41.0) Female: 1.85-12.5 mol FFA · h ^-1 · g Tissue ^-1 (

: 6.63) 30.8-208U / kg (

: 110) (2) Muscle tissue male: 0.42-1.65 mol FFA · h ^-1 · g tissue ^-1 (

: 0.87) 7.0-27.5U / kg (

: 14.5) Female: 0.38-1.55 mol FFA · h ^-1 · g Tissue ^-1 (

: 0.90) 6.3-25.8U / kg (

15.0) (3) Serum plus heparin: 396 ± 81nmol FFA · min ^-1 · ml ^-1 (

± s) 396 ± 81U / L (

± s) 170 ± 50U without heparin 70 ± 50nmol FFA · min ^-1 · ml ^-1 (

± s)

Clinical significance of lipoprotein lipase

Moderate reduction in LPL activity is seen in diseases such as type 1 hyperlipoproteinemia, hypertriglyceridemia, diabetes, renal failure, lymphoma, and prostate tumors. Deficiency is first reflected in extrahepatic adipose tissue. Increased LPL activity is seen in hepatitis, pancreatitis, cirrhosis, and pancreatic tumors.

Lipoprotein lipase considerations

Heparin, lead, calcium, bile salts, lecithin, and lysolecithin can all activate lipoprotein lipase, and oral contraceptives can cause decreased activity.
(1) LPL is localized in the liver and extrahepatic tissues.
(2) LPL activity was significantly reduced in fasting samples.
(3) FFA shows free fatty acids.