What Is Chronic Epstein-Barr?

Aipositan-Ba'er ershi bindu ganran Epstein-Barr virus infection (EBV infection) An infection caused by EB virus, a herpes virus. Epstein-Barr virus (EBV) is short for Epstein-Barr virus (EBV). In 1963, when MA Epstein and YM Barr performed tissue culture of Burkitt's lymphoma cells from children in Africa, Found, hence the name.

Epstein-Barr virus infection

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Aipositan-Ba'er ershi bindu ganran Epstein-Barr virus infection (EBV infection) An infection caused by EB virus, a herpes virus. EB

This virus is a lymphotropic virus, belonging to the herpesvirus family group, which can infect human and primate B lymphocytes.

Epstein-Barr virus infection is very common. In areas with poor socio-economic conditions, the population is infected earlier with EB virus, the EB virus antibody positive rate is high, and there are no obvious clinical symptoms after infection. In areas with better socioeconomic conditions, EB virus infection occurs after puberty, and most often manifest as infectious mononucleosis.

EB virus is transmitted through saliva. Epstein-Barr virus infection mainly manifests in the following forms, and its clinical manifestations, diagnosis methods and treatments are different. The diagnostic method of EB virus is to detect the specific antibodies of EB virus. Because of the carcinogenic potential of EB virus, its attenuated or dead vaccines are of certain risk. Membrane antigen vaccines are under study.

Primary recessive infections are more common in children. About 90 to 100% of children under the age of 3 in third world countries have been infected with EBV. No clinical symptoms appear after infection, but specific anti-EBV antibodies are present in the serum. After infection, EBV can form a persistent latent infection in human B lymphocytes and oropharyngeal epithelial cells, and continuously excreted through saliva to infect healthy people.

Infectious mononucleosis is more common in adolescents and adults with negative anti-EBV antibodies. Main manifestations are fever, sore throat, cervical lymphadenopathy, and splenomegaly. Peripheral blood lymphocytes increase, reaching 50 to 60%, and atypical lymphocytes appear, generally above 10%. Hematopoietic agglutination test and anti-EBV antibody positive, in patients with immunodeficiency, can show chronic, recurrent infectious mononucleosis. The prognosis of this disease is good, mainly symptomatic treatment.

Burkitt's lymphoma is a malignant lymphoma in children in Equatorial Africa and New Guinea. When Burkitt's lymphoma cells were cultured, EBV genes and EBV-specific antigens were found in the tumor cells. In the serum of patients with Burkitt's lymphoma, there are high titers of anti-EBV capsid antigen (VCA) antibodies (antibody titer 1: 160, and the positive rate can reach more than 80%). The antibody-positive rate was only 5 to 15%. Some monkeys have been experimentally infected with the Epstein-Barr virus to cause malignant lymphoid tissue hyperplasia similar to Burkitt's lymphoma. Therefore, it is currently believed that African children have severe and persistent EBV infection in infants and young children, and malaria infection has occurred on the basis of EB virus infection, immune function is suppressed, tumor genes are activated, resulting in the malignant proliferation of B lymphocytes, forming a primary Tew's lymphoma.

Nasopharyngeal carcinoma EBV infection may be one of the causes (especially undifferentiated nasopharyngeal carcinoma). Studies have shown that EBV genes and EBV-specific antigens can be found in cancer cells by culturing living cells of nasopharyngeal carcinoma. At the same time, a variety of EBV antibodies were found in the serum of patients with nasopharyngeal carcinoma. In sera and saliva of patients with nasopharyngeal carcinoma, the titer and positive rate of EBV-specific IgA antibodies were significantly higher than those of normal people and other tumor patients. Detection of EBVIgA antibody can be used as a sensitive and reliable indicator for the general screening, diagnosis, and determination of curative effect and prognosis of patients with nasopharyngeal carcinoma. ^[1]

EBV infection in patients with immunodeficiency and organ transplantation. Due to severe immunodeficiency, EBV of long-term latent infection in the body is activated, causing viremia and severe infection of multiple organs, such as hepatitis, encephalitis, pneumonia . Serious infections or generalized systemic infections can cause death.