What Is Immunological Synapse?

Immune synaptic structure refers to a transient structure formed by close contact between T cells and APC surface adhesion molecules through receptor-ligand interactions. The structure is based on the TCR-MHC-antigen peptide ternary structure as a cluster. Adhesive molecules are distributed in a ring-shaped center. The formation of this structure helps T cells to distinguish potential antigens, improves the affinity between TCR and MHC-antigen-peptide complexes, and thus initiates the recognition and activation of T cells. Some studies have shown that only immune synapses are formed T cells of the structure can proliferate. ^[1]