What Is the Connection Between the Papilloma Virus and Cervical Cancer?

Human papillomavirus (HPV) is an epithelial virus, widely distributed in humans and animals, and highly specific. The host of human papillomavirus (HPV) is named "human" for humans. HPV can cause benign tumors and warts in humans, such as human common warts, condyloma acuminatum, and papilloma that grow on the mucous membranes. HPV is a double-stranded closed-loop small DNA virus that contains approximately 8,000 base pairs. These include 8 early open reading frames (E1-E8), 2 late reading frames, and a non-coding long control area. In the early open reading frame, E6 and E7 genes are most important for cell growth stimulation. E6 and E7 proteins encoded by E6 and E7 bind to tumor suppressor genes p53 and Rb, respectively, causing uncontrolled cell proliferation and damage to DNA by tumor suppressor genes. Loss of repair function, leading to the occurrence of precancerous lesions and cancer. The L1 and L2 genes in the late reading frames encode the major and minor capsid proteins of HPV, respectively, and assemble into HPV capsids. Since zur Hansen proposed that HPV is a carcinogenic factor of cervical cancer in 1976, the research on the relationship between HPV infection and cervical cancer has become a hot topic in the study of the cause of tumor virus. ^[1]

Human papilloma virus

HPV is a general term for a group of viruses, forming a family. The virus morphology is similar, but the DNA restriction endonuclease maps are different.

Research on the prevalence of HPV infections varies according to the source of the test specimens, the HPV detection technology used, the type of HPV detected, and the population differences in the study area.

The level of HPV infection mainly depends on the age of the population and

Since HPV infection usually has no obvious clinical symptoms, its

HPV infection and

Viral analysis has identified 100 types of human papillomatosis. Types 6 and 11 are found to be low-risk and have few developmental abnormalities; types 16, 18, 31, 33, 35, and 45 are highly dangerous and often cause developmental abnormalities. The vast majority of anal human papillomavirus infections are type 6 and type 11.

Human papilloma virus causes at least 10 human diseases. Common is

Patients and carriers of human papilloma are the main source of infection. Human papillomavirus infection is one of the most common sexually transmitted diseases in the United States. It is highly infectious and is most commonly transmitted by sexual contact. It can be transmitted to others before warts develop or without obvious symptoms. In addition, close contact,

Most anal

Prevention of human papilloma virus is mainly to avoid sexual contact. Using condoms during sex can help prevent the spread of HPV. Clinical studies have shown that men who use condoms more often than men who use condoms occasionally or never.

Human papilloma virus itself cannot heal itself, and the main purpose of treatment is to relieve the symptoms and treat warts. The drugs that patients can use on their own are 0.5% podofilox, 5% imiquimod ointment (imiquimod ointment), and gels. The drugs that need to be used under the guidance of a doctor are 10% -25% podophyllotoxin, 80% -90 % Trichloroacetic acid. In addition, interferon and laser can also be used for treatment. After a diagnosis of genital warts, a leather wart wipe is recommended.

1. The appearance is relatively typical (such as rough surface, papillary appearance, cauliflower-like appearance, chicken crown-like appearance, granulation, meat-like appearance, etc.).

2, the appearance of atypical warts can rely on the acetic acid white test to differentiate the diagnosis. The acetic acid white test can be done at home by preparing 3% -5% acetic acid (the concentration of edible white vinegar is 4% -6%, which can be used as a condyloma acuminatum). Apply white vinegar-soaked gauze or paper towel to the growing growth, and observe whether the protrusions turn white after 3 to 5 minutes (the warts on the anal area take 10 to 15 minutes). Can be diagnosed as genital warts.

3. If the appearance is not typical, and the result of the acetic acid white test is not obvious, you can go to the hospital for a histopathological examination to diagnose. If the characteristic concave hollow cells can be detected, the diagnosis can be confirmed. An additional point is that there is no scientific basis for the diagnosis of genital warts by blood tests, and it is not accurate. Normal large hospitals generally do not adopt this diagnostic method.