What Are the Pros and Cons of Using Gene Therapy for Cancer?

This book introduces the basic knowledge of molecular biology of cancer, explains the gene therapy of cancer, and introduces experimental research and clinical trials of various malignant tumors in the form of gene therapy monographs.

Gene therapy for cancer

This book introduces the basic knowledge of molecular biology of cancer, expounds the gene therapy of cancer, and treats the malignant tumors in the form of gene therapy monographs.

In addition to domestic scholars, the authors of this book have also collaborated with scholars who are studying or working in the United States, including some scholars from Yale University School of Medicine, Columbia University School of Medicine, Baylor College of Medicine, Pfizer Pharmaceuticals, and Seattle Cancer Research Center We write together. These scholars have some accomplishments in molecular biology, and some are engaged in in-depth research in this area and have made certain achievements. However, the editors also feel that we are far from enough to write such a monograph that is developing so fast and the content and technology are so complicated, both in terms of common sense and experience. If there is any contribution from this book, we believe that organizing scholars from China and the United States to brainstorm, exchange and discuss with each other is very beneficial to the development of science and technology in China and is worthy of improvement and promotion in the future. ^[1]

introduction

Molecular detection of cancer

Second, the main new molecular detection technology

Gene therapy for cancer

Fourth, the gene vector

V. Prospects and Problems of Cancer Gene Therapy

Some social issues related to gene therapy

The first molecular biology overview of cancer

Chapter 1: Oncogenes and Tumor Suppressor Genes (Anti-oncogenes)

I. Oncogene

Tumor suppressor genes

Chapter 2 The Cell Cycle

I. Regulation of g1 molecular

Second, s-phase gene regulation

Third, g2 / m phase gene regulation

Fourth, the molecular regulation mechanism of the m phase

The role of extracellular signals

Checkpoint regulation of the cell cycle

Cell cycle and cancer

Eight, cell cycle abnormalities and tumor treatment issues

Chapter 3 Cell Signaling and Cancer

I. Types of cell signal transduction and general characteristics of transduction pathways

Biological effects of signal transduction

3. Several major signal transduction pathways in cells and cancer

Four other important signal transduction pathways in cells and cancer

V. Signal Transduction and Cancer Treatment

Chapter 4 Molecular Biology and Tumor of Apoptosis

First, the concept of apoptosis

Core molecules involved in apoptosis

Signal transduction of apoptosis

Four, apoptosis regulators and tumorigenesis

Chapter 5 Telomeres, Telomerase and Tumors

I. History of Discovery

Telomeres

Telomerase

Four, telomerase activity detection method

V. Telomerase structural protein and telomere binding protein

Telomeres, telomerase and tumors

Seven, outlook

Chapter 6 Invasion and Metastasis of Cancer Cells

I. Basic concepts of tumor invasion and metastasis

Molecular mechanisms of tumor invasion and metastasis

Chapter 7 Molecular Targeted Therapy for Cancer

First, small molecule compounds

Protein drugs

Third, p53 anti-oncogene

Chapter VIII Introduction of therapeutic genes and application of vectors

I. Non-viral strategies

Viral strategies

Chapter IX Antisense Technology and Ribozyme Technology

First, antisense technology

Second, ribozyme technology

Chapter 10 RNA interference technology

First, the principle of RNA interference

Biological functions of RNA interference

RNA interference in mammals

Fourth, the experimental technology of RNA interference

V. Application of RNA interference in biomedicine and functional genome

Chapter 11 Cancer-Guided Molecular Chemotherapy

Classification of cancer-directed molecular chemotherapy

Common strategies for cancer-oriented molecular chemotherapy

Selection of tumor-targeted molecular chemotherapy drug carriers

Chapter XII Melting Antitumor Simplex