What is the use of glimepiride and pioglitazone?
doctors prescribe glimepiride and pioglitazone to control blood glucose in patients diagnosed with diagnosis mellitus dependent on non -nidDM, commonly called diabetes 2. Although both drugs perform similar actions. Health care providers may prescribe glimepiride and pioglitazone with other oral antidiabetic drugs for an increased effect of glucose decreasing. Studies suggest that patients taking oral antidiabetic drugs have an increased risk of cardiovascular disease. Pharmaceutical companies also combine sulfonyl and metformin into one formulation. The advantages of glimepiride include a decrease in circulating blood sugar levels as a physician stimulates the pancreatic beta cell to release insulin. Glimepiride and pioglitazone also increase the sensitivity to insulin tissue, reducing insulin resistance. Oral anti-diabetic also inhibits the release of sugar from the liver. Pioglitazone stimulates the places of the cellular receptor, causing chemiA reaction that changes the transmission of genetic material in genes that control glucose and lipid control. In addition to regulating blood sugar levels, the benefits of pioglitazone also include reduced triglycerides and increased high density lipoproteins (HDL).
patients usually take one dose of both drugs in the morning. Glimepiride and pioglitazone can be used with or without food. Both drugs can cause side effects, but side effects associated with pioglitazone are generally more serious. Glimepiride diabetics can experience dizziness, headaches, nausea and generalized weakness and individuals with allergies to sulfa drugs may develop reactions to glimepiride. The combination of drugs with other antidiabetic substances increases the risk of hypoglycaemia.
The side effects associated with pioglitazone include symptoms similar to cold or influenza, headache and muscle pain. Patients who take it can also take the nature ofa weight stek caused by an increase in greasy tissue or a generalized swelling. Pioglitazone is not recommended in patients with advanced heart failure and the drug may deepen the symptoms of mild to medium heart disease. A small number of patients will also develop macular edema, which is the accumulation of fluids behind the eye.
Research shows that patients using pioglitazone may experience a slight decrease in the number of red blood cells. Women taking a medicine have a slightly increased risk of bone fracture suffering. In addition, pioglitazone disrupts the action of oral contraceptives and caused ovulation in premenopausal women.