What factors affect sufficient dose of ceftriaxone?
ceftriaxone is a strong antibiotic recommended for a wide range of diseases and prevents infection due to surgery. The recommended dose of ceftriaxone changes according to the condition to be treated and its severity. Dosage adjustments may also be required depending on age, weight, liver health and the level of kidney function.
adults who receive treatment for bacterial infection can receive between 1 and 2 grams of drugs a day in one or two divided doses. The more serious the infection, the higher the dose of ceftriaxone is needed. If the drug is not well tolerated or if the drug levels must remain constant, then more divided doses are more advantageous than a single daily dose. For the treatment of stapylococcus aureus , which is observable with methicillin, the total daily dose of ceftriaxone between 2 and 4 grams should be. More than 4 grams should never be provided in 24 hours.
The manufacturer recommends that pediatric patients aged older month get an intravenous dose of ceftriaXon between 50 and 75 mg per 2,2 pounds (1 kg) of body weight in one to two divided doses every 12 to 24 hours in severe bacterial infections. More than 2 g should not be given within one 24 hours. Pediatric patients with life -threatening bacterial infection may receive intravenous dose of ceftriaxone 80 to 100 mg per pound (1 kg) per to two divided doses per day. These patients should not receive more than 4 g of medicines per day.
The recommended dose of ceftriaxone for infants less than one month is somewhat lower than the dose in other pediatric patients. Infants between eight days and four weeks of age and weighing below £ 4.4 (£ 2,000) should receive 50 mg for £ 2.2 (1 kg) body weight, while heavier infants can receive between 50 and 75 mg per day. The heavier infants of the AME should receive the same dose every 24 hours. Infants aged eight days and four weeks and weighing below 4.4 pounds (2,000 g) should receive 50 mg per 2,2 poundsEnce can receive 50 to 75 mg daily. This medicine should not be used in infants with hyperbilirubinaemia because in vitro studies have shown that ceftriaxone can cause serum albumin bilirubin in these patients, causing encephalopathy.
The above dosage recommendations may need to be adjusted for patients suffering from a reduction in the function of the liver and kidney function. It is assumed that only the liver or just kidney dysfunction suffers for the patient; However, patients with reduced liver and kidney function may not require a dose of ceftriaxone greater than 2 g per day. Higher doses should not be used unless the serum drug levels are monitored.