What Factors Affect a Sufficient Ceftriaxone Dose?

The antibacterial spectrum of ceftriaxone sodium is similar to that of ceftriaxone sodium. It has a strong effect on E. coli, pneumococcus, indole-positive proteus, influenza bacterium, serratia, meningococcus, and gonococcus; pneumococcus, streptococcus, and staphylococcus aureus are moderately sensitive to this product; false to aeruginosa Monascus has certain effects. Enterococci, methicillin-resistant Staphylococcus, and most B. fragile bacteria are resistant to this product.

Basic Information

Drug Name: Ceftriaxone sodium
Alias: Ceftriaxone Sodium
Whether prescription drugs: prescription
Main indications: Treatment of respiratory infections, urinary system infections, gonorrhea

Dosage: Intramuscular injection, adult 1g / time, 1 time / day
Main medication contraindications: Allergic to cephalosporin antibiotics
Athletes use with caution: Inadvertent use
Whether to include health insurance: Incorporate

Ceftriaxone sodium indication

It is used for pneumonia, bronchitis, peritonitis, pleurisy caused by sensitive bacteria, and skin and soft tissue, urinary tract, biliary tract, bone and joint, facial features, wounds and other parts of infection. It is also used for sepsis and meningitis. Simplex gonorrhea

Clinical application of ceftriaxone sodium

The daily dose for adults is 1-2g, once daily, intramuscularly or intravenously, not exceeding 4g per day. Children: Severe (except meningitis), 50 to 75 mg / kg (not more than 2 g per day), given in two divided doses, given intravenously. Meningitis: 4g daily for adults, divided into 2 doses (not more than 4g daily), administered intravenously. Gonorrhea: 250mg once intramuscularly. Preventive medication before surgery: 1/2 to 2 hours before surgery, intramuscular injection of 1g. The renal function or the liver function is impaired, generally do not need to adjust the dose, but the severe renal function or the liver and the renal function are insufficient at the same time should measure the blood concentration and control the dosage.

Ceftriaxone sodium adverse reactions

Allergic reactions can cause rashes, fever, and itching. Appetite deficiency, nausea, vomiting, and diarrhea appear in the digestive system. Abnormal liver function. Transient blood urea nitrogen and creatinine increase. Occasionally white blood cells, neutrophils, thrombocytopenia, and eosinophilia increased. Long-term medication can cause secondary infections such as candidiasis and pseudomembranous enteritis.

Ceftriaxone sodium precautions

Allergic to penicillin. Severe liver and kidney dysfunction should be used with caution. Adolescents and children using this product may occasionally cause gallstones, but they can disappear after stopping the drug. In newborns, do not use calcium-containing solutions within 48 hours after using this product. This product cannot be used in solutions containing calcium such as Hartmann and Ringer. Ceftriaxone is contraindicated in newborns who are or are receiving calcium-containing intravenous products.

Ceftriaxone sodium contraindications

Those who are allergic to cephalosporins are prohibited.

Ceftriaxone sodium drug interactions

Combined with aminoglycosides, it has a synergistic antibacterial effect, but it may also aggravate kidney damage. The combined use of this product with calcium-containing agents or calcium-containing products may cause adverse events of fatal outcome; this product can affect ethanol metabolism and Acetaldehyde concentration in blood increased, disulfiram-like reaction occurred; probenecid did not affect the elimination of this product. In vitro tests found that the combination of chloramphenicol and ceftriaxone had an antagonistic effect.

Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.