What Is Autologous Chondrocyte Implantation?

Stem cells are a class of pluripotent cells with self-renewal and self-replication capabilities. Under certain conditions, it can differentiate into a variety of APSC pluripotent cells, which is a type of primitive cells with the potential for self-replication and multidirectional differentiation.

Autologous stem cell transplantation

Under certain conditions, it can differentiate into multiple

(1) Safety: low toxicity (or non-toxic);

(2) It can also be applied before the exact mechanism of disease onset is fully understood;

(3) Adequate sources of treatment materials;

(4) Wide treatment scope;

(5) is the best carrier for immunotherapy and gene therapy;

(6) Traditional therapy considers "

Autologous stem cell transplantation is mainly divided into two steps, namely

First, confirm the patient's

Scientists have always believed that if stem cells can be used, the tissues and organs that are cultivated are of great significance for the treatment of cancer and many other malignant diseases. Using stem cell transplantation technology

(1) Femoral head necrosis

Femoral head necrosis is a name for aseptic ischemic necrosis of the femoral head. It is a disease caused by poor blood flow to the femoral head due to a variety of reasons, which causes ischemia, necrosis, trabecular fracture, and collapse of the femoral head. The long course of disease and high disability rate seriously endanger people's health. Using femoral artery puncture minimally invasive technology, genetically modified autologous stem cells were superselectively transplanted into multiple blood supply arteries in the femoral head area. Within a period of time after surgery, new blood vessels can appear locally in the femoral head, improve local blood circulation in the femoral head, and significantly improve local ischemic symptoms. At the same time, it promotes the regeneration of osteoblasts in the necrotic area of the femoral head, and the new bone cells fill the bone defect of the femoral head, and gradually restore the physiological function of the hip joint. The treatment method is safe and painless, and the long-term observation has a definite curative effect, and is especially suitable for early patients who have not yet severely deformed the femoral head.

advantage:

Stem cells are autologous, without cross-infection, and without ethical issues

After genetic modification of stem cells, it is more conducive to transform into osteoblasts. At the same time, the transferred genes have a significant function of promoting vascular regeneration, which can effectively improve local blood circulation in the femoral head.

The treatment process is safe and simple. Vascular intervention is a minimally invasive treatment with less pain and short hospital stay (usually about 7 days in hospital)

The curative effect is good. The effective rate of early patients (stage and ) is more than 90%, and advanced patients (stage and ) can also be used with conventional surgery to transplant stem cells to increase the efficacy of surgery.

No obvious side effects, suitable for patients of any age

(2) Ischemic diseases of lower limbs, including diabetic foot, arterial thromboangiitis obliterans, etc.

Diabetic foot, thrombo-occlusive vasculitis, and arteriosclerotic occlusive disease are common clinical diseases caused by lower limb ischemic disability. High morbidity, high disability and high mortality seriously affect people's quality of life, and even endanger life. According to research reports, the incidence of chronic lower extremity arteriosclerosis and ischemia in people over 60 years of age is 17-20%, and the rate of amputation is as high as 5%. In recent years, with the deepening and development of research on stem cells, scientists have discovered that stem cells can be transformed into vascular endothelial cells in the lower extremity of ischemia, thereby promoting the regeneration of local blood vessels. At the same time, the stem cells transplanted to the local area can also secrete a large number of cytokine factors to nourish peripheral nerve cells and improve the function of peripheral nerves. The results of clinical research show that after transplanting stem cells to the ischemic lower limbs, new blood vessels appear locally in the lower limbs, blood circulation is improved, the clinical symptoms of lower limb ischemia are significantly relieved, and a good therapeutic effect is obtained. This method is safe and reliable, and it is a brand new treatment method.

advantage:

Stem cells are derived from the body, no cross infection, no ethical issues

Genetically modified stem cells provide both vascular regeneration stem cells and bioactive molecules necessary for vascular regeneration, greatly accelerating the rate and capacity of vascular regeneration

Transfected genes have nutritional and repairing effects on ischemic nerve endings and significantly relieve lower limb pain

High treatment efficiency, small toxic and side effects, safe, convenient and effective treatment process

(3) Cirrhosis

Autologous bone marrow stem cell transplantation for liver cirrhosis is a new type of minimally invasive interventional surgery that has only recently been launched in our country. The long-term effects are well documented in some medical websites abroad. There are no long-term cases of autologous bone marrow stem cell transplantation in China for liver cirrhosis, but its short-term effect is still very obvious. The principle is to use the directional differentiation characteristics of stem cells to make them differentiate into liver cells to replace those that have been lost or necrotic. In order to achieve the purpose of treatment, it is like using your own stem cells to change your liver for yourself. The risk of surgery is very small, there is no rejection after surgery, not to mention the cost of more than 2,000 anti-rejection drugs every month to maintain as in liver transplantation.
However, autologous bone marrow stem cell transplantation is also limited. If liver cancer has been combined, do not perform this operation.

(4) Autoimmune diseases, mainly including systemic lupus erythematosus, rheumatoid arthritis, etc.

(5) Treatment of sequelae of cerebral thrombosis and cerebral hemorrhage

Cerebral thrombosis and cerebral hemorrhage are common clinical diseases with high disability and mortality rates. With the acceleration of the aging process in China, the incidence is getting higher and higher. Most patients with cerebral thrombosis and cerebral hemorrhage have different degrees of neurological damage symptoms after onset, such as aphasia, hemiplegia, urinary and stool disorders, etc., how to promote the repair of damaged brain tissue and the recovery of neural function is particularly important. In recent years, with the deepening of stem cell research, the repair and functional reproduction of various irreversible brain injuries caused by cerebrovascular diseases have become a reality. Many scholars have applied different methods to inject stem cells directly into the ischemic brain, and found that some of them can survive in the brain, migrate to the damaged site, and partly proliferate and differentiate into damaged and missing nerve cells.

Hepatocyte growth factor (HGF) is a normal growth factor in the human body and a multifunctional growth factor. Current research finds that HGF can promote the regeneration of nerve cells and repair nerve damage, while HGF can promote the regeneration of blood vessels in ischemic sites. HGF gene-modified stem cells are transplanted to the damaged part of the brain by means of minimally invasive methods. It not only provides the stem cells required for nerve injury but also cytokines that promote nerve cell proliferation and repair nerve damage. Vascular regeneration accelerates the recovery of neural function under the action of multiple repair mechanisms.

advantage:

· Stem cells have three functions after genetic modification: they can differentiate into nerve cells; secreted HGF promotes regeneration and repair of damaged nerve cells; HGF promotes blood vessel regeneration in ischemic sites

· Vascular intervention is a minimally invasive treatment with less pain and requires only one treatment. The whole process is safe and simple.