What is the hydrobromide galantamine?
Galantamine hydrobromide is a derivative of a natural product of galantamine and is used to treat the symptoms of early and middle Alzheimer's disease. One model of the effect of this disease is that the amount of neurotransmitter acetylcholine is limited, which negatively affects memory and learning. Treatment with anticholinesterase, an enzyme inhibitor that breaks down acetylcholine, should then help increase the amount of acetylcholine in the brain and reduce symptoms. For this purpose, several types of anticholinesterases were commercially used, among them galantamine hydrobromine. Some medical staff considers this class of drugs ineffective in the treatment of symptoms of Alzheimer's disease. The research was carried out in the 1950s in the Soviet Union and this compound was isolated, identified, and used to treat various central nervous system disorders. The drug can now be made synthetically and, after being formulated as a galantamine hydrobromide, is sold as a medicine of Alzheimer's disease.
Galantamine hydrobromide inhibits the decomposition of acetylcholine, a neurotransmitter that is important for factors that reduce the patient of Alzheimer. The company involved in learning and memory is considered limited in the brains of people with this disease. It was assumed that the treatment of patients with a drug that limits the decomposition of acetylcholine, caused an increase in the amount of neurotransmitter in the brain, thus limiting the symptoms of Alzheimer's disease. The advantage of galantamine is that it is competitive and reversible, so it is not fatal as anticholinesterase such as snake or poisonous gas.
It is very important that the patient starts at the lowest dose of galantamine hydrobromide and then the scale was to increase very much gradually. The drug aims to affect symptoms and does not reduce the progression of the disease. It may take up to three months to see any effect. Individuals may differ in how they are influenced by this drug.
There are great differences in the way nGalantamine hydrobromide metabolizes galantamine. Most drug metabolism takes place in the liver and a small percentage of the population are so -called slow metabolizers. They degrade Alzheimer's disease much longer because they lack a certain type of enzyme metabolizing drug. The drug dose is titrated for each person.
The side effects of galantamine hydrochloride can be quite unpleasant and consist of vomiting and nausea. Modification of the patient's diet can help alleviate these effects. The severity of the side effects and the low degree of improvement led to the conclusion that anticholinesterase therapy is not guaranteed. The current pathology models focus on beta amyloid plaques that are formed in the brain.