What is opioid potentiation?
The term "potentiation" concerns an increase in the effectiveness of the drug through the action of other compounds. Layouts can occur when taking other medicines, consuming certain foods or using some food supplements. Opioid potentiation generally concerns an increase in opioid therapies that are usually used to treat pain. Some individuals using opioids use potentiation to gain greater therapeutic benefit from their drugs without having to increase the dosage. Knowledge of potentiation can also help individuals who use opioids, avoid unintentionally increasing the effects of their drugs.
There are several different ways to potioid potentiation. Opioids decompose or metabolized enzymes in the liver and some other substances with better ability to bind to these enzymes effectively slow down the speed, that opioids decompose, causing them effective for a longer period of time. Some compounds, Liantacids, change the acidity of the stomach, allowing opioids more easilyenter the bloodstream. Laying can also take place in a brain where some medicines may have synergistic effects with opioids, which increases their efficiency.
A wide range of compounds can cause opioid potentiations, and some of them are more common medicines, foods and beverages that patients of pain therapy should be aware of. High fat meals can also help some opioids passing through the stomach by lining into the bloodstream, causing an increase in their intensity. Grapefruit juice contains several compounds that inhibit liver enzyme activity, which usually help break down these drugs. When consuming 30 minutes to an hour before receiving opiate analgesics for pain, their effects can be strengthened and last for a long time.
Similar effects on liver enzymes can appear a number of drugs. Antacid cimetidin can apply this effect and thus can dextrOmethorfan, suppressing cough. In this way, however, all opioid analgesics will not occur. Some medicines such as codeine must be metabolized into other forms to be effective. The use of these types of drugs with substances that inhibit liver enzymes actually reduce their efficiency.
In the brain itself, opioid potentiation can occur in several ways, with different drugs. Antihistamines, such as dipenhydramine, may increase the properties of opioids inducing sleep without necessarily increasing the effect of pain treatment. However, other drugs such as caffeine or non -steroidal anti -inflammatory compounds such as aspirin may intensify the properties of opioids renanding pain. Individuals who take them should explore the possibility of interaction with other medicines, food supplements and common foods that may be aware of, may cause potentiations that could cause potentials.