What is the interaction between codeine and tramadol?

Codein and tramadol are analgesics used to treat medium to moderate pain. Both drugs do not interact with each other, but should not take together. At the same time, the acceptance of codeine and tramadol increases the risk of respiratory depression. At the same time, the use of both drugs increases the risk of seizures, especially in people who have already been in favor of seizures. It can be derived directly from the poppy poppy or synthesized from morphine. Tramadol is a synthetic compound that is not chemically related to medicines in opiate class. No drug has anti -inflammatory properties. Codein and tramadol have similar relierce pain properties and can usually be used interchangeably.

TRAMADOL Analgesic effect is not fully understood, although the studies have revealed some ways to control pain. Tramadol does not contain opids, but works similarly to codeine in imitating natural endorphins of the body. Endorphins bind to opoid receptors in the brain and block the transmission of nerve pain to the brain. Tramadol also increases the effects of serotonin, thus frommouts pain.

both codeine and tramadol cause the same constellation of side effects related to opids. Dizziness, nausea and constipation are common when taking one drug. The run of two drugs together can increase their severity. There is also a higher incidence of severe side effects when codeine and tramadol are used simultaneously.

Tramadol has been shown to reduce the threshold value of seizures, causing seizure activity in predisposed patients using recommended doses. Codein has the same effect, though not as much as tramadol. It has been shown that the simultaneous use of both drugs significantly reduces the threshold value of seizures, even in patients who are not susceptible to seizures. In addition, the IS there is an increased risk of respiratory depression associated with the use of codeine. Tramadol has a minimum risk of respiratory depression, but the use of codeine and tramadol aggravates the effect and may cause serious PR risko patients with respiratory problems.

The use of tramadol can re -initiate non -oopoid dependence in patients previously dependent on opids. Although tramadol does not contain opids, it is considered a non -oopoid drug because it binds to opoid receptors. Tramadol produces the effects similar to codeine and should not be used as a substitute for codein in patients with addiction problems. Tramadol and codeine are addictive drugs. The level of dependence depends on the prescribed dosage and the duration of the drug time.