What Are Leydig Cells?
Sertoli-Leydig cell tumor is composed of Sertoli cells with different degrees of differentiation, tumor cells similar to testicular epithelial cells, tumor cells similar to fibroblasts and Leydig cells. The tumor tissue can be composed of a single cell or a mixture of multiple cells. .
Sertoli-Leydig cell tumor
- nickname
- Sertoli-Leydig cell tumor
- TCM disease name
- Male blastoma
- English name
- Sertoli-Leydig
- Common symptoms
- The section is cystic and local bleeding
- Sertoli-Leydig cell tumor is composed of Sertoli cells with different degrees of differentiation, tumor cells similar to testicular epithelial cells, tumor cells similar to fibroblasts and Leydig cells. The tumor tissue can be composed of a single cell or a mixture of multiple cells. .
- Sertoli-Leydig cell tumor, also known as male blastoma, is rare. It consists of Sertoli cells with different degrees of differentiation, tumor cells similar to testicular reticulocytes, fibroblasts and Leydig cells. The tumor tissue can be composed of a single Seed cells or a mixture of cells.
- [1]
- Sertoli-Leydig cell tumor immunohistochemistry revealed that sex cord and stroma were vimentin, CK, a-inhibin positive to varying degrees. Occasionally, EMA is positive. ER and PR were positive in a few reported cases. Leydig cells are negative for CK, CAM5.2, and AFP, while vimentin and a-inhibin are strongly positive, which can help distinguish them from hepatocellular carcinoma. The immunohistochemical performance of the heterologous component is the same as that of the tissue from which it originated. Mucinous epithelium expresses strongly CK7, EMA is positive, and muscle-derived components express actin and desmin. Reticular Sertoli-Leydig cell tumor immunohistochemistry revealed that the reticular region expresses CK and moderate a-inhibin, while the sex cord interstitial region is opposite. Vimentin is expressed in the nucleus.
- 1 In the case of moderate differentiation, the cut surface is cystic and local hemorrhage.
- 2 Sertoli cell nests are visible around the slices of Leydig cells, and the adjacent area is edema
- This disease is more common in the ovary. Because the patient has clinical signs of virilization and pelvic deduction into the mass, the 17 hydroxy and 17 ketones in hematuria are further measured, and the ACTH stimulation test and DXM inhibition test are performed with the adrenal or ovarian tumor. Signs that cause virilization.
- Because the tumor is sometimes small and difficult to determine even during surgery, some authors have proposed it. If the tumor cannot be confirmed during the operation, wedge ovary biopsy should be performed.