What Is a Sertoli Cell?

Sertoli cells

The latest research shows that sertoli cells are in the seminiferous tubules next to germ cells. These cells are not part of the germ cell line. They are located on the basement membrane of seminiferous tubules and extend into the human lumen, branching into the middle of germ cells at different stages. It has been thought for years that sertoli cells provide only structural support in the testes. It is now recognized that they have many important functions. In adults, they play an important role in the release of sperm into the seminiferous tubules. They also provide an important barrier, separating the lumen from the rest of the seminiferous tubules' sperm-producing areas, and they produce androgen-binding proteins. Spermatogonial cells and adjacent sertoli cells are juxtaposed on the basement membrane. This acts as a functional barrier between the interstitial space and the fluid that soaks the reproductive epithelium. The fluid in the seminiferous tubules is substantially different from the blood, plasma or lymph components of the testes. It contains less protein and 3 times more potassium without glucose. There were also significant differences in amino acid concentrations; the amount of glutamic acid and aspartic acid in testicular fluid was higher than blood. Most importantly, the basement membrane prevents proteins from entering the seminiferous tubules. This protects the contents and does not work with blood antibodies that can react with sperm. Testosterone can spread freely through the basement membrane. Testicular reticulum concentrations have been found to be similar to testicular venous blood. Therefore, hormones important for spermatogenesis can be effectively transported, and other substances in the blood circulation that can interfere with this process are excluded.

1. Form blood-testis barrier

2. Secretory media promotes sperm production and maturation

3. Synthesis and secretion of androgen binding protein

4. Secrete inhibin, inhibit the release of pituitary FSH

5. Secretory media affects mediator cells

6. Devour sperm

7. secrete testicular fluid to promote sperm excretion