What is reverse triodothyronine?

Reverse triodothyronine, also known as reverse T3 or RT3, is one of the hormones produced by the thyroid gland. The thyroid function is to regulate metabolism and excrete mainly hormones T4 or thyroxine and T3 or triodothyronine, but the reverse T3 is also produced in small quantities. Triiodotronines is an active thyroid hormone and when the circulating thyroxine reaches the body tissue, part of it is converted to triodothyronine. Reverse triodothyronine, which is inactive, is a by -product of this conversion process and most of them are created in this way. Increased levels of reverse triodothyronine sometimes occur in patients who have a serious disease. About 95 percent of reverse triodothyronin in the village is created during T4 transformation into T3 deodinase enzymes. The remaining five percent is produced by the thyroid gland.

There are many different situations in which reverse t levels can be increasedriodothyronin. It is known that a larger amount of reverse T3 is formed on the fetus along with lower triodothyronine levels. The levels of the reverse T3 drop by several weeks after birth to match the levels of normal adults. Fasting initially causes a decrease in T3 and increases the reverse T3, while longer -term starvation sees reverse triodothyronine levels returning to normal. Overeating has the opposite effect, with an increase in T3 and RT3 decrease.

Some drugs may affect deiodinase enzymes, inhibiting their effects and lead to a reduction in T4 conversion into T3 in body tissues and lack of selenium may have a similar effect. In what the euthyroid syndrome, a serious illness such as cancer, kidney and liver failure, infections, infections and burns, suppress deiodine enzymes, refers to the Euthyroid Sick syndrome. This means that it may be difficult to assess the thyroid function in people who are seriously ill because the levels of thyroid hormones may be abnormal in the absence of thyroid disease. At the euthyr syndromeOid Sick, although the amount of T3 produced by the thyroid remains the same, reduced tissue conversion causes a reduction in the total T3 level. Less reverse T3 is cleaned from the body, resulting in reverse triodothyronine levels.