What Is the Role of Dopamine?

Dopamine injection is a drug, which is a sterile aqueous solution of dopamine hydrochloride. Dopamine hydrochloride (C8H11NO2.HCl) should be 93.0% to 107.0% of the labeled amount.

Dopamine injection

Dopamine injection is a medicine for

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[Usage and Dosage] Usual Adult

[Precautions] Cross-allergic reactions: Patients who are highly sensitive to other sympathomimetic amines may also be extremely sensitive to this product. The research on human body is not enough, and there is no teratogenicity in animal experiments. It has been reported that pregnant rats have reduced the survival of newborn pups and that survivors have potential for cataract formation. Pregnant women must weigh the pros and cons when using it. (3) Whether this product is discharged into milk is not determined, but there is no problem in the application of nursing mothers. This product has not been fully studied in children. The application of this product in the elderly has not been fully studied, but no problems have been reported. The following cases should be used with caution: Not suitable for patients with pheochromocytoma: Occlusive angiopathy (or those with previous history), including arterial embolism, atherosclerosis, thromboangiitis obliterans, frostbite (such as frostbite) , Diabetic arterial endocarditis, Raynaud's disease, etc. with caution; patients with poor circulation of the extremities must be closely monitored to pay attention to the possibility of necrosis and gangrene; should be used with caution when frequent ventricular arrhythmias . Monitoring of blood pressure, cardiac output, electrocardiogram and urine volume should be performed during infusion of this product. Dosage instructions Hypovolemia must be corrected before dopamine treatment. It must be diluted before instillation. The concentration of the diluent depends on the dose and the amount of fluid required by the individual. If no volume expansion is required, a 0.8 / ml solution can be used. If liquid retention occurs, a 1.6-3.2 / ml solution can be used. Medium and small doses have no effect on peripheral vascular resistance and are used to treat hypotension caused by low cardiac output; larger doses are used to increase peripheral vascular resistance to correct hypotension. Use a thick vein for intravenous injection or intravenous drip to prevent fluid leakage and tissue necrosis; if liquid spillage does occur, a 5-10 g phentolamine diluted solution can be used for infiltration at the injection site. Intravenous drip rate should be controlled per minute. The drip rate and time should be determined according to blood pressure, heart rate, urine volume, peripheral vascular perfusion, ectopic pulsation, etc. The cardiac output should be measured when possible . When the shock is corrected, the drip rate is slowed down. In case of excessive contraction of blood vessels, the diastolic blood pressure increases disproportionately, the pulse pressure decreases, the urine volume decreases, the heart rate increases or arrhythmia occurs. The drip rate must be slowed down or suspended. If blood pressure continues to drop during dopamine infusion or hypotension continues after adjusting the dose, dopamine should be discontinued and a stronger vasoconstrictor should be used instead. Sudden discontinuation of medication can cause severe hypotension, so it should be gradually reduced when discontinued.
[Medication for pregnant women and lactating women] It is not clear [Drug interactions] Combined with sodium nitroprusside, isoprenaline, dobutamine, pay attention to changes in cardiac output, the response is different than when using this product alone . High-dose dopamine is equivalent to alpha blockers such as phenoxybenzamine, phentolamine, and tolazoline. The vasodilator effect of the latter can be antagonized by the contraction of peripheral blood vessels of this product. (3) Combined with general anesthetics (especially cyclopropane or halogenated hydrocarbons) because the latter can make the heart muscle abnormally sensitive to dopamine, causing ventricular arrhythmias. Rhenium is used in combination with -blockers, which can antagonize the effect of dopamine on the heart's 1 receptor. Used together with nitrates, it can reduce the anti-angina and nitrate boosting effects of nitrate. Use with diuretics. On the one hand, this product acts on dopamine receptors to dilate the renal blood vessels and increase renal blood flow, which can increase the diuretic effect; on the other hand, the product itself has a direct diuretic effect. When used together with guanethidine, it can strengthen the pressure effect of dopamine, weaken the antihypertensive effect of guanethidine, and cause hypertension and arrhythmia. The simultaneous application of tritium and tricyclic antidepressants may increase the cardiovascular effects of dopamine, causing arrhythmia, tachycardia, and hypertension. Used together with monoamine oxidase inhibitors, it can prolong and strengthen the effect of dopamine. It is known that this product is metabolized by monoamine oxidase. Patients who have received monoamine oxidase inhibitors 2 to 3 weeks before dopamine, the initial amount is reduced to at least 1 / 10. Simultaneous intravenous injection of thallium and phenytoin can produce hypotension and bradycardia. In the case of dopamine, if the anticonvulsant treatment with phenytoin is necessary, the alternate use of the two drugs must be considered. [Drug dopamine hydrochloride injection]