What Is an Idiotype?
Idiotype
Idiotype
- Chinese name
- Idiotype
- Foreign name
- idiotype
- Condition
- same
- Idiotype
- It refers to the variable region of the immunoglobulin molecule produced by different B cell clones of the same individual with different antigen specificity, and the type distinguished from this is called idiotype. Idiotypic epitopes are mainly determined by amino acid differences in the hypervariable regions.
- In the middle of this century, it was discovered that injecting Ig into the same or different animals can induce the production of anti-Ig antisera. It was subsequently discovered that there are two types of epitopes on the Ig molecule, namely isotypes and allotypes. In 1955, when Slater et al. Studied the specificity of rabbit anti-human myeloma protein antiserum, they found that the anti-some myeloma protein antiserum was fully absorbed with unrelated other myeloma proteins or normal human Ig, and was still used as the original immunogen The type of myeloma protein reacted, and they called this new antigenic specificity present on Ig as "individual 'antigenic specitficities."
- Refers to the same
- In 1963, Oudin et al. Immunized 50 rabbits with Salmonella typhimurium, using the anti-Salmonella typhi antibody isolated from the serum of one rabbit as an immunogen, immunizing normal rabbits, and isolating the serum to obtain anti-antibodies. The study found that this anti-antibody can only react frequently with anti-Salmonella typhimurium antibodies as immunogens, but not with the serum of the remaining 49 Salmonella typhimurium-immunized rabbits.
- Idiotype is mainly through anti-idiotypic antibodi
- In 1974, Jerne proposed that the epitope is called an epitope (Epitope, E), and the binding site complementary to E on the antibody molecule is called a paratope (P). Jerne assumes that an epitope can be recognized by several types of complements with different precisions. Similarly, a complement can be combined by several different epitopes. Jerne referred to several epitopes existing in the V region of the antibody molecule as idiotopes (idiotope, i) such as il, i2, etc., and believed that the idiotype of the antibody was composed of all the unique positions on the antibody molecule. Each Fab segment on the antibody molecule has a complement and a set of about 5-6 unique positions.