What is an idiotype?
Idiotype is a set of amino acids that are unique to the antibody and determine its specificity - in other words to which the antigens are tied. The idiotype study is important for immunologists who need to understand how the body produces and uses antibodies. It is possible to use idiotypes in the production of the vaccine to start the patient to start producing suitable antibodies and protect against certain antigens. These amino acids can be sequential in a laboratory environment. One antibody can have more idiotypes. The idiotype is extremely specific - so much that people can sometimes respond to their own idiotypes and will certainly respond to those who are introduced from other people or species. When it is intentionally done with a vaccine, it can stimulateimize the antibody production that resists infectious diseases.
This is one method of classification of antibodies. At a slightly wider level, antibodies can be classified by allotype, genetic changes in the antibody structure that may reflectGenetic heritage. Nearly relatives tend to have similar allotypes, but can respond against allotypes produced in the bodies of people who are not relatives. This may be a problem with procedures such as blood transfusions in which comparison of antibodies is decisive for the prevention of side effects.
even wider antibodies can be classified by isotype, which is characteristic observed in all members of the same kind. For example, immunoglobulin M is a human isotype, a protein that occurs in any person, except for those who have a genetic disorder that disrupts the immune function. The progressive classification of antibodies can help scientists to study antibodies and their functions.
idiotype is highly unique; Only antibodies that have the same specificity will have the same idiotype, but antibodies that have different specificities can have the same isotypes and allotypes. Scientists can use a laboratorTesting to identify specific idiotypes in the sample and sequence is to learn more about how they work. It is possible to use laboratory animals to produce human idiotypes specific specificity for use in research and development of new vaccines. Variations of idiotype can also explain why people could have antibodies to one tribe of the disease, but not others, because they cannot be blocked on antigens with which they are not designed to be paired, as seen in the case of the flu.